14149-34-9

Basic information

• Product Name: 3-Phenylpiperidine-2,6-dione
• Synonyms: 3-Phenyl-2,6-piperidinedione;3-Phenylpiperidine-2,6-dione
• CAS NO: 14149-34-9
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.2105
• Mol File: 14149-34-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 392.3°Cat760mmHg
• Flash Point: 176.6°C
• Appearance: /
• Density: 1.185g/cm³
• Vapor Pressure: 2.31E-06mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 3-Phenylpiperidine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenylpiperidine-2,6-dione(14149-34-9)
• EPA Substance Registry System: 3-Phenylpiperidine-2,6-dione(14149-34-9)

Safety Data

• Hazardous Substances Data: 14149-34-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11NO2/c13-10-7-6-9(11(14)12-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,12,13,14)

Upstream product

• 88611-73-8 methyl 4-cyano-4-phenylbutanoate 
• 19748-87-9 ethyl 4-cyano-4-phenylbutanoate 
• 10444-19-6 4-cyano-2-phenylbutyric acid ethyl ester 
• 101-97-3 Ethyl 2-phenylethanoate 
• 140-29-4 phenylacetonitrile 
• 860621-29-0 N-tert-butyl-2-phenylethanimidamide 
• 860621-31-4 methyl 3-[1-(N-t-butylamino)-2-phenylethylidene]aminopropionate 
• 860621-32-5 6-t-butylamino-5-phenyl-4,5-dihydro-3H-pyridin-2-one 
• 91137-66-5 2-phenylpentanedinitrile 
• 2628-87-7 2-phenylglutaric acid 

Downstream Products

• 92137-90-1 3-(4-Amino-phenyl)-piperidine-2,6-dione 
• 51551-56-5 (RS)-3-phenylpiperidin-2-one 
• 92137-91-2 3-(4-nitrophenyl)piperidine-2,6-dione 

Relevant articles and documents

Degradation mechanism of glutethimide and other 2,6-dioxopiperidines in the mass spectrometer

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Copper-Catalyzed Enantioselective Cyano(Fluoro)Alkylation of Alkenes

A copper-catalyzed asymmetric cyano(fluoro)alkylation reaction of alkenes is reported. A range of chiral fluoroalkyl cyanides were obtained in high yields and excellent enantiomeric excess from readily available chemicals. The method uses fluoroalkyl iodi

Synthesis of heterocyclic compounds using amidines as their ene-1,1-diamine tautomers. I. Synthesis of 4,5-dihydro-3H-pyridin-2-one, 3,4-dihydropyrrol-2- one and 1,3-dihydropyrrol-2-one derivatives by the reaction of amidines with α,β-unsaturated esters

N-t-Butylacetamidines 1 on heating with methyl acrylate (2) at 200° gave the 4,5-dihydro-3H-pyridin-2-one derivatives 5. Michael addition of the acetamidines 1 as their ene-1,1-diamine tautomers 1′ to 2 and the subsequent cyclization of the adducts gave derivatives 5. Amidines 1 on reaction with trimethyl ethylenetricarboxylate (9) or dimethyl acetylenedicarboxylate (12) afforded 3,4-dihydropyrrol-2-one 11 or 1,3-dihydropyrrol-2-one derivatives 13.