1416134-47-8

Basic information

• Product Name: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate
• Synonyms: (2s,5r)-ethyl 5-((benzyloxy)amino)piperidine-2-carboxylate oxalate;(2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate;2-Piperidinecarboxylic acid, 5-[(phenylmethoxy)amino]-, ethyl ester, (2S,5R)-
• CAS NO: 1416134-47-8
• Molecular Formula: C15H22N2O3
• Molecular Weight: 278.35
• Mol File: 1416134-47-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 391.2±52.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: 7.47±0.10(Predicted)
• CAS DataBase Reference: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate(1416134-47-8)
• EPA Substance Registry System: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate(1416134-47-8)

Safety Data

• Hazardous Substances Data: 1416134-47-8(Hazardous Substances Data)

Usage

General Description

C₁₅H₂₂N₂O₃ is the chemical formula for levocetirizine, an antihistamine medication used to treat allergies and hay fever. C₁₅H₂₂N₂O₃ belongs to the class of drugs known as second-generation antihistamines, which are generally less sedating than first-generation antihistamines. Levocetirizine works by blocking the action of histamine, a substance in the body that is responsible for allergy symptoms such as itching, sneezing, and watery eyes. It is available in oral tablet or liquid form and is often used to relieve symptoms such as runny nose, itching, and hives caused by allergic reactions. Common brand names for this medication include Xyzal and Levrix.

Upstream product

• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 1416134-58-1 ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate 
• 144978-12-1 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate 
• 56-86-0 L-glutamic acid 

Downstream Products

• 2064219-13-0 (2R,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid 
• 1174020-25-7 (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid 

Relevant articles and documents

Method of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylic acid or a derivative thereof

The present application relates to methods of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylic acid or its derivatives in an environment-friendly way. The method uses L-glutamic acid as a starting material, which is first subjected to esterification reaction in the presence of an acidic reagent, and then reacted successively with 2-haloacetate and N-protecting agent, or with N-protecting agent and 2-haloacetate under a basic condition to obtain compound IV; then, the obtained compound IV is subjected to intramolecular condensation into a ring under the action of a strong base to obtain N-protecting group piperidine-5-one-2S-carboxylate (V).

DIAAZABICYCLOOCTANONE DERIVATIVES AS ANTIBACTERIALS

The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-P-lactamase enzymes, in combination with antibiotics.

MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, R