141987-52-2

Basic information

• Product Name: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, acetate, (S)-
• CAS NO: 141987-52-2
• Molecular Formula: C12H15ClO4
• Molecular Weight: 258.702
• Mol File: 141987-52-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, acetate, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, acetate, (S)-(141987-52-2)
• EPA Substance Registry System: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, acetate, (S)-(141987-52-2)

Safety Data

• Hazardous Substances Data: 141987-52-2(Hazardous Substances Data)

Upstream product

• 150-76-5 4-methoxy-phenol 
• 2211-94-1 2,3-epoxypropyl p-methoxyphenyl ether 
• 108-22-5 Isopropenyl acetate 
• 25772-85-4 (+/-)-1-chloro-3-(4-methoxyphenyloxy)-2-propanol 
• 108-05-4 vinyl acetate 

Downstream Products

• 2211-94-1 4-methoxybenzyloxy ester of (S)-glycidol 

Relevant articles and documents

A facile and convenient chemoenzymatic synthesis of optically active O-(4-methoxyphenyl)-glycidol and 1,2-diacyl-sn-glycerol

A convenient preparation of the (R)- and (S)-enantiomers of O-(4-methoxyphenyl)-glycidol by a one-pot reduction of ketone 3 and in situ lipase mediated resolution is described. Activated moist aluminium oxide in the presence of Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) has been found effective for the transesterification leading to a high degree of enantioselectivity. These chiral glycidols were further used as a chiral precursor for the synthesis of biologically important 1,2-O-diacyl-sn-glycerol under mild reaction conditions. The present method is facile for the synthesis of chiral glycidols in high enantioselectivity when compared to the previously reported methods.

Enzyme Assisted Preparation of Enantiomerically Pure β-Adrenergic Blockers III. Optically Active Chlorohydrin Derivatives and Their Conversion

Optical active chlorohydrin derivatives 2a-m and 3a-m of both enantiomeric series were prepared via both enzymatic hydrolyses and acyltransfer reactions catalysed by a highly selective lipase from Pseudomonas sp..The resulting building blocks were further transformed into the corresponding β-blockers of high enantiomeric purity.