142035-70-9

Basic information

• Product Name: (R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate
• Synonyms: (R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate
• CAS NO: 142035-70-9
• Molecular Weight: 251.282
• Mol File: 142035-70-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate(142035-70-9)
• EPA Substance Registry System: (R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate(142035-70-9)

Safety Data

• Hazardous Substances Data: 142035-70-9(Hazardous Substances Data)

Usage

Description

(R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate, also known as MXB, is a chemical compound with the molecular formula C16H19NO4. It is a derivative of the amino acid valine and is a chiral compound, meaning it has two mirror-image forms, or enantiomers. MXB is commonly used as a building block in organic synthesis and is an important intermediate in the synthesis of various pharmaceuticals and biologically active compounds due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Research and Development:
(R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate is used as a building block in the pharmaceutical industry for the synthesis of various pharmaceuticals and biologically active compounds. Its unique chemical structure and properties make it a valuable intermediate in the development of new drugs.
Used in Organic Synthesis:
In the field of organic chemistry, (R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate is used as a key intermediate for the synthesis of complex organic molecules. Its chiral nature allows for the creation of enantiomerically pure compounds, which are essential in various applications, including the development of new drugs and specialty chemicals.
Used in the Production of Specialty Chemicals and Fine Chemicals:
(R)-Methyl 3-(((benzyloxy)carbonyl)aMino)butanoate is also utilized in the production of specialty chemicals and fine chemicals, where its unique properties and reactivity are harnessed to create high-value products for various applications, such as agrochemicals, fragrances, and dyes.

Upstream product

• 121054-27-1 Methyl (+/-)-3-<(benzyloxycarbonyl)amino>butanoate 
• 100-51-6 benzyl alcohol 
• 501-53-1 benzyl chloroformate 
• 139243-54-2 (R)-3-aminobutanoic acid methyl ester hydrochloride 
• 26607-51-2 N-benzyloxycarbonyl-D-alanine 
• 67-56-1 methanol 
• 68223-06-3 (3-diazo-1-(R)-methyl-2-oxopropyl)carbamic acid benzyl ester 
• 6078-06-4 (R)-methyl 3-aminobutanoate hydrochloride 
• 134430-97-0 methyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)butanoate 
• 623-43-8 methyl crotonate 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 105499-10-3 (R)-benzyl-(1-methyl-2-oxoethyl)carbamate 
• 105-45-3 acetoacetic acid methyl ester 
• 621-84-1 O-benzyl carbamate 

Downstream Products

• 323592-68-3 6-(S)-methylpiperazin-2-one 
• 1350922-84-7 (R)-benzyl [1-(2-(2-aminoethyl)-1,3-dioxan-2-yl)propan-2-yl]carbamate 
• 1350922-82-5 (R)-benzyl [4-oxo-hex-5-en-2-yl]carbamate 
• 1350922-83-6 (R)-benzyl [6-(1,3-dioxoisoindolin-2-yl)-4-oxo-hexan-2-yl]carbamate 
• 1256379-69-7 C₃₇H₅₁N₃O₈ 
• 1256379-76-6 2-methyl-3-aminobutyric acid 
• 1443463-61-3 C₁₄H₁₉NO₄ 
• 866395-21-3 (-)-(3R)-3-((benzyloxycarbonyl)amino)butanol 
• 1425668-87-6 benzyl (2R,6R)-4,4-dimethoxy-2-methyl-6-nonylpiperidine-1-carboxylate 
• 1425668-80-9 benzyl (7R,9R)-7-methyl-9-undecyl-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate 
• 1425668-82-1 benzyl (7R,9S)-7-methyl-9-undecyl-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate 
• 947530-25-8 C₂₂H₂₅NO₄ 
• 1431706-23-8 C₂₂H₂₅NO₄ 
• 1425666-89-2 (R)-benzyl [5-(diethoxyphosphoryl)-4-oxopentan-2-yl]carbamate 

Relevant articles and documents

Synthetic method of (R)-3- n-aminobutanol (by machine translation)

The invention belongs to, the field (R)- 3 - of pharmaceutical and chemical engineering, and particularly relates to a method for. preparing a product (R)- 3 - with good chemical purity, and optical, purity by, a, preparation method of a chiral drug midbody . (by machine translation)

Efficient synthesis of β'-amino-α, β-unsaturated ketones

A general and simple procedure to access chiral β'-amino-α, β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner-Wadsworth-Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.

Stereoselective synthesis and in vivo evaluation of the analgesic activity of polysubstituted bispidines

Hetero-Michael addition on a chiral β'-amino α,β- unsaturated ketone gave, after some structural modifications, β,β'-diamino ketals. Mannich-type reactions of these diamines with an aldehyde led, with high diastereoselectivity, to trisubstituted piperidines. Another highly stereoselective Mannich cyclization, with an N-acyliminium ion generated in situ from the corresponding imide, allowed the preparation of original polycyclic bispidine derivatives. The antinociceptive effect of the three compounds prepared was evaluated in vivo by using the writhing test. If the biological results for the analgesic properties were disappointing, compared with the bispidine HZ2, which has a high affinity for opioid receptors, the modularity of the approach offered the possibility of introducing many substituents for new applications, which was promising because the bispidine core has been described to have many different activities. Total stereoselective synthesis of bispidine derivatives is achieved by using as two successive Mannich reactions key steps. This process constitutes a powerful approach toward the preparation of a polycyclic bispidine backbone with high enantioselectivity.