1421275-66-2 Usage
General Description
2,5-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrrole is a complex organic compound with a chemical structure consisting of a pyrrole ring with two methyl and one substituted phenyl group attached to it. Additionally, a boron-containing group is attached to the phenyl ring, making it a boron-containing compound. This chemical has potential applications in the field of organic synthesis, especially in the development of new materials and pharmaceuticals. The boron-containing group also suggests potential use in cross-coupling reactions for carbon-carbon bond formation. Overall, this compound is important in the field of organic chemistry and has potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1421275-66-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,2,7 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1421275-66:
(9*1)+(8*4)+(7*2)+(6*1)+(5*2)+(4*7)+(3*5)+(2*6)+(1*6)=132
132 % 10 = 2
So 1421275-66-2 is a valid CAS Registry Number.
1421275-66-2Relevant articles and documents
Synthesis and biological activity of new 4-(Pyridin-4-yl)-(3-methoxy-5- methylphenyl)- 1H-pyrazoles derivatives as ROS Receptor tyrosine kinase inhibitors
Park, Byung Sun,El-deeb, Ibrahim M.,Yoo, Kyung Ho,Han, Dong Keun,Tae, Jin Sung,Lee, So Ha
, p. 3629 - 3634 (2013/01/16)
A series of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles (6a-k & 7a-l) has been rationally designed based on the structure of the lead compound KIST301080, a selective ROS receptor tyrosine kinase inhibitor, in order to study the activity of ROS of this new class of inhibitors. The compounds were synthesized and screened against ROS kinase, where compound 6h showed moderate inhibitory activity with an IC50 value of 6.25 μM. The study emphasized the importance of the acetonitrile group at the pyrazole ring and also the importance of having a hydrogen bond donor on the distal phenyl ring linked to the pyridine moiety.