5044-24-6

Basic information

• Product Name: 1-(4-BROMOPHENYL)-2,5-DIMETHYL-1H-PYRROLE
• Synonyms: AKOS BB-3545;1-(4-BROMOPHENYL)-2,5-DIMETHYL-1H-PYRROLE;1-(4-BROMOPHENYL)-2,5-DIMETHYLPYRROLE;2,5-Dimethyl-1-(4-bromophenyl)-1H-pyrrole
• CAS NO: 5044-24-6
• Molecular Formula: C₁₂H₁₂BrN
• Molecular Weight: 250.13
• Mol File: 5044-24-6.mol
• Article Data: 36

Chemical Properties

• Melting Point: 75-77°C
• Boiling Point: 320.2 ºC at 760 mmHg
• Flash Point: 147.5 ºC
• Appearance: powder
• Density: 1.31 g/cm³
• Vapor Pressure: 0.000604mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: -3.33±0.70(Predicted)
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-2,5-DIMETHYL-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-2,5-DIMETHYL-1H-PYRROLE(5044-24-6)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-2,5-DIMETHYL-1H-PYRROLE(5044-24-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5044-24-6(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)-2,5-dimethyl-1H-pyrrole is a chemical compound with the molecular formula C12H12BrN. It is a pyrrole derivative, which is a type of five-membered aromatic ring with one nitrogen atom. 1-(4-Bromophenyl)-2,5-dimethyl-1H-pyrrole is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is also known for its potential as a building block in the development of organic electronic materials. 1-(4-Bromophenyl)-2,5-dimethyl-1H-pyrrole has a wide range of applications in various industries, making it an important and versatile chemical compound.

InChI:InChI=1/C12H12BrN/c1-9-3-4-10(2)14(9)12-7-5-11(13)6-8-12/h3-8H,1-2H3

Upstream product

• 110-13-4 2,5-hexanedione 
• 106-40-1 4-bromo-aniline 
• 1333-74-0 hydrogen 
• 586-78-7 para-nitrophenyl bromide 
• 109-49-9 5-Hexen-2-one 
• 74-86-2 acetylene 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 

Downstream Products

• 15898-26-7 4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid 
• 83935-45-9 4-(2,5-dimethyl-1H-pyrrol-1-yl)-acetophenone 
• 83756-25-6 2-<4-(2,5-dimethylpyrrol-1-yl)benzilidene>-1,3-dithian 
• 95337-70-5 4-(2,5-dimethylpyrrol-1-yl)benzaldehyde 
• 95337-69-2 1-[1-(4-Bromo-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2,2,2-trifluoro-ethanone 
• 106-40-1 4-bromo-aniline 
• 131817-91-9 (E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-phenyl]-2-propenoic acid 
• 1421275-66-2 2,5-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrrole 
• 1430818-46-4 diethylammonium [N,N-bis(2,6-diisopropylphenyl)-4-(2,5-dimethylpyrrole-1-yl)benzamidinatotetrachlorotitanate] 

Relevant articles and documents

Amidosulfonic acid supported on graphitic carbon nitride: novel and straightforward catalyst for Paal–Knorr pyrrole reaction under mild conditions

A novel heterogeneous acidic catalyst was prepared by in situ immobilization of amidosulfonic acid (NH2SO3H) on graphitic carbon nitride (g-C3N4) under hydrothermal conditions. The textural morphology of NH2SO3H/g-C3N4 nanocomposite was characterized via powder X-ray diffraction, FT-IR, TGA, EDX, and scanning electron microscopy. The spatial arrangement of the amidosulfonic acid on the surface of g-C3N4 leads to the construction of a unique solid acid structure, resulting in a substantial enhancement of catalytic activity toward a high efficient preparation of pyrroles by Paal–Knorr reaction. The reactions undergo completion readily with good to excellent yields, with simple purification in an environmentally friendly manner. The NH2SO3H/g-C3N4 nanocomposite can be readily recycled, and no noteworthy reduction in the catalytic activity detected after four runs. Graphic abstract: [Figure not available: see fulltext.]

Method for preparing N-aryl pyrrole compound

The present invention relates to a method for preparing an N-aryl pyrrole compound. Furan containing different substituents, aromatic amine containing different substituents and a solid Lewis acid catalyst are mixed and placed in a closed reactor, and an N-aryl pyrrole compound with different substituents is prepared under certain catalytic conditions. The reaction temperature of the catalytic reaction condition is 140-210 DEG C. The solid Lewis acid catalyst is prepared by a sol-gel method, Hf is used as a core metal element, and a mesoporous molecular sieve SBA-15 is used as a carrier. According to the method, the catalyst is simple to prepare, low in cost, high in reaction activity, good in water resistance and structural stability and high in catalytic reaction yield; meanwhile, the Lewis acid type catalyst does not generate acid protons, the corrosion of the catalyst to equipment at high temperature is avoided, the post-reaction treatment is convenient, and the catalyst is renewable and environment-friendly.

Fe3O4@SiO2-PTMS-Guanidine-SA nanoparticles as an effective and reusable catalyst for the synthesis of N-substituted pyrroles

Fe3O4@SiO2-PTMS-Guanidine-SA nanoparticles used as an effective catalyst for the synthesis of N-substituted pyrroles. Pyrroles were synthesized from the reaction between primary amine derivatives and 2,5-hexanedione with high to excellent yields under mild reaction conditions. After completion of the reaction, Fe3O4@SiO2-PTMS-Guanidine-SA magnetic nanoparticles could be recovered easily from the reaction mixture by an external magnet and reused. This catalyst was characterized by FT-IR spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, thermogravimetric analysis and vibrating-sample magnetometry techniques.