1421697-72-4

Basic information

• Product Name: (4S,12bS)-4-o-tolyl-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one
• Synonyms: (4S,12bS)-4-o-tolyl-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one
• CAS NO: 1421697-72-4
• Molecular Weight: 484.619
• Mol File: 1421697-72-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4S,12bS)-4-o-tolyl-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,12bS)-4-o-tolyl-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one(1421697-72-4)
• EPA Substance Registry System: (4S,12bS)-4-o-tolyl-12-tosyl-1,3,4,6,7,12b-hexahydroindolo[2,3-a]quinolizin-2(12H)-one(1421697-72-4)

Safety Data

• Hazardous Substances Data: 1421697-72-4(Hazardous Substances Data)

Upstream product

• 869096-24-2 9-tolylsulfonyl-4,9-dihydro-3H-β-carboline 
• 16927-82-5 (E)-4-(2-methylphenyl)but-3-en-2-one 
• 61-54-1 tryptamine 
• 529-20-4 2-methylphenyl aldehyde 
• 145865-96-9 4,9-dihydro-9-(p-toluenesulfonyl)-3H-pyrido-<3,4-b>indole 
• 4894-26-2 3,4-dihydro-β-carboline 
• 6502-82-5 N_b-formyltryptamine 

Relevant articles and documents

Oxidative asymmetric formal aza-Diels–Alder reactions of tetrahydro-β-carboline with enones in the synthesis of indoloquinolizidine-2-ones

Ru-catalyzed tandem amine oxidative dehydrogenation/formal aza-Diels–Alder reaction for enantio- and diastereoselective synthesis of indoloquinolizidine-2-ones from tetrahydro-β-carbolines and α,β-unsaturated ketones is described. The reaction proceeds via tandem ruthenium-catalyzed amine dehydrogenation using tert-butyl hydroperoxide (TBHP) as the oxidant and a chiral thiourea-catalyzed formal aza-[4 + 2] cycloaddition, providing a step-economical strategy for the synthesis of these valuable heterocyclic products.