1424942-80-2

Basic information

• Product Name: (R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate
• Synonyms: (R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate
• CAS NO: 1424942-80-2
• Molecular Weight: 446.481
• Mol File: 1424942-80-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate(1424942-80-2)
• EPA Substance Registry System: (R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate(1424942-80-2)

Safety Data

• Hazardous Substances Data: 1424942-80-2(Hazardous Substances Data)

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 1117893-59-0 4-(4-((R)-5-benzyloxymethyl-2-oxo-oxazolidin-3-yl)phenyl)morpholin-3-one 
• 1447919-65-4 4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one 
• 1313613-18-1 [4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester 
• 446292-04-2 4-(4-nitrophenyl)-3-morpholinone 
• 122-98-5 2-Anilinoethanol 
• 29518-11-4 4-phenylmorpholin-3-one 
• 1117893-60-3 4-{4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 1446022-14-5 butyric acid-2(R)-2-hydroxy-3-[4-(3-oxo-morpholin-4-yl)phenylamino]-propyl ester 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 
• 1447919-71-2 4-(4-((R)-5-((phenyloxycarbonyloxy)methyl)-2-oxo-oxazolidin-3-yl)phenyl)-morpholin-3-one 
• 1447919-69-8 acetic acid-1-benzyloxymethyl-2-{[(R)-(3-oxo-morpholin-4-yl)-phenyl]-chlorocarbonyl-amino} ethyl ester 
• 1447919-68-7 acetic acid-1-benzyloxymethyl-2-[(R)-4-(3-oxo-morpholin-4-yl)phenylamino]-ethylester 

Downstream Products

• 1446022-16-7 (S)-4-(4-(5-(aminomethyl)-2-oxo-oxazolidin-3-yl)phenyl)morpholin-3-one formate salt 
• 366789-02-8 Rivaroxaban 
• 1446022-18-9 (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one L-(+)-mandelate 
• 446292-08-6 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 
• 1252018-26-0 4-[4-((R)-5-(iodomethyl)-2-oxo-oxazolidin-3-yl)phenyl]-morpholin-3-one 
• 1251952-73-4 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt 
• 1349248-79-8 4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one 
• 446292-10-0 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one 
• 1429333-90-3 5-chloro-N-[{(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl]-N-benzyl-2-thiophene carboxamide 
• 1372665-04-7 4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 1424942-78-8 4-{4-[(5S)-5-(N-benzylaminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morphoIin-3-one 
• 1430407-73-0 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one oxalate 

Relevant articles and documents

Rivaroxaban intermediate preparation method

The invention discloses a rivaroxaban intermediate preparation method. 4-(4-aminophenyl)morpholinyl-3-one and S-glycidol as staring raw materials are synthesized into a compound shown in the structural formula (IV), wherein in the formula (IV), R represents methyl, p-methylphenyl, phenyl or trifluoromethyl. The rivaroxaban intermediate preparation method has the advantages of mild reaction conditions, operation simpleness, high yield and industrialization easiness.

PROCESSES AND INTERMEDIATES FOR PREPARING RIVAROXABAN

The invention discloses processes for the preparation of rivaroxaban and its pharmaceutically acceptable salts, solvates, and hydrates thereof. The invention also relates to novel intermediates for the preparation of rivaroxaban.