1426955-68-1

Basic information

• Product Name: (R)-(-)-4-triisopropyloxybenzyl-α-d chloride
• CAS NO: 1426955-68-1
• Molecular Weight: 299.92
• Mol File: 1426955-68-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-(-)-4-triisopropyloxybenzyl-α-d chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-4-triisopropyloxybenzyl-α-d chloride(1426955-68-1)
• EPA Substance Registry System: (R)-(-)-4-triisopropyloxybenzyl-α-d chloride(1426955-68-1)

Safety Data

• Hazardous Substances Data: 1426955-68-1(Hazardous Substances Data)

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 95307-62-3 α-(4-benzyloxyphenyl)-α-morpholinoacetonitrile 
• 95307-63-4 α-(4-benzyloxyphenyl)-α-morpholino<α-2H>acetonitrile 
• 50816-33-6 4-benzyloxybenzaldehyde 
• 95307-64-5 4-hydroxybenzaldehyde 
• 1426955-67-0 4-triisopropylsilyloxybenzaldehyde-α-d 
• 1426955-64-7 (S)-(+)-4-triisopropylsilyloxybenzyl-α-d alcohol 

Downstream Products

• 1426955-69-2 (2S,3S)-N-benzoyl-O-triisopropylsilyl-[3-²H,¹⁵N]-tyrosine (-)-8-phenylmenthyl ester 
• 1426955-71-6 (2S,3S)-N-benzoyl-[3-²H,¹⁵N]-tyrosine (-)-8-phenylmenthyl ester 
• 1426955-73-8 (2S,3S)-[3-²H,¹⁵N]-tyrosine hydrochloride 

Relevant articles and documents

Chirally deuterated benzyl chlorides from benzyl alcohols via hexachloroacetone/polymer-supported triphenylphosphine: Synthesis of protected (2S, 3S)-[3-2H, 15N]-tyrosine

Chirally deuterated benzyl chlorides were prepared using novel, general hexachloroacetone/polymer-supported triphenylphosphine treatment of chirally deuterated benzyl alcohols. Doubly labeled protected tyrosine was obtained in 62% yield with 86% de at the α-carbon and 82% de at the β-carbon. Key in the synthesis was the alkylation of 15N-labeled (-)-8-phenylmenthylhippurate with R-(-)-4-triisopropylsilyloxybenzyl-α-d chloride. Chirally deuterated benzyl chlorides were prepared in high yield with inversion from benzyl alcohols using solid-phase methods. One of the benzyl chlorides obtained was used in the synthesis of protected tyrosine labeled with 15N and chirally deuterated on the β-position. Copyright