50816-33-6

Basic information

• Product Name: 4-BENZYLOXYBENZALDEHYDE-ALPHA-D1
• Synonyms: 4-BENZYLOXYBENZALDEHYDE-ALPHA-D1;4-BENZYLOXHYBENZALDEHYDE-ALPHA-D1;4-Benzyloxybenzaldehyde-α-D1
• CAS NO: 50816-33-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 213.25
• Mol File: 50816-33-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BENZYLOXYBENZALDEHYDE-ALPHA-D1(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXYBENZALDEHYDE-ALPHA-D1(50816-33-6)
• EPA Substance Registry System: 4-BENZYLOXYBENZALDEHYDE-ALPHA-D1(50816-33-6)

Safety Data

• Hazardous Substances Data: 50816-33-6(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 32122-11-5 4-benzyloxy-benzoic acid methyl ester 
• 95307-63-4 α-(4-benzyloxyphenyl)-α-morpholino<α-2H>acetonitrile 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 1486-51-7 p-(benzyloxy)benzoic acid 
• 95307-62-3 α-(4-benzyloxyphenyl)-α-morpholinoacetonitrile 

Downstream Products

• 1426955-73-8 (2S,3S)-[3-²H,¹⁵N]-tyrosine hydrochloride 
• 1426955-71-6 (2S,3S)-N-benzoyl-[3-²H,¹⁵N]-tyrosine (-)-8-phenylmenthyl ester 
• 1426955-69-2 (2S,3S)-N-benzoyl-O-triisopropylsilyl-[3-²H,¹⁵N]-tyrosine (-)-8-phenylmenthyl ester 
• 1426955-68-1 (R)-(-)-4-triisopropyloxybenzyl-α-d chloride 
• 50816-34-7 (S)-(+)-4-benzyloxybenzyl-α-d alcohol 
• 1426955-64-7 (S)-(+)-4-triisopropylsilyloxybenzyl-α-d alcohol 
• 1426955-67-0 4-triisopropylsilyloxybenzaldehyde-α-d 
• 95307-75-8 (+/-)-4',7-dibenzyloxy<2,3,3-2H3>flavanone 
• 95307-74-7 (+/-)-4',7-dibenzyloxy<2-2H>flavanone 
• 95307-66-7 2',4,4'-trihydroxy<β,3,5-2H3>chalcone 
• 95307-76-9 2',4,4'-trihydroxy<α,β-2H2>chalcone 
• 95307-65-6 4-hydroxybenzaldehyde 
• 95307-64-5 4-hydroxybenzaldehyde 

Relevant articles and documents

SYNTHESIS OF DEUTERATED ALDEHYDES

Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D2O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

Formyl-selective deuteration of aldehydes with D2O: Via synergistic organic and photoredox catalysis

Formyl-selective deuteration of aldehydes is of high interest for labeling purposes and for optimizing properties of drug candidates. Herein, we report a mild general method for formyl-selective deuterium labeling of aldehydes with D2O, an inexpensive deuterium source, via a synergistic combination of light-driven, polyoxometalate-facilitated hydrogen atom transfer and thiol catalysis. This highly efficient, scalable reaction showed excellent deuterium incorporation, a broad substrate scope, and excellent functional group tolerance and selectivity and is therefore a practical method for late-stage modification of synthetic intermediates in medicinal chemistry and for generating libraries of deuterated compounds.

Deoxygenative Deuteration of Carboxylic Acids with D2O

We report a general, practical, and scalable means of preparing deuterated aldehydes from aromatic and aliphatic carboxylic acids with D2O as an inexpensive deuterium source. The use of Ph3P as an O-atom transfer reagent can facilitate the deoxygenation of aromatic acids, while Ph2POEt is a better O-atom transfer reagent for aliphatic acids. The highly precise deoxygenation of complex carboxylic acids makes this protocol promising for late-stage deoxygenative deuteration of natural product derivatives and pharmaceutical compounds.