142738-55-4Relevant articles and documents
Solid-phase synthesis of oligodeoxynucleotides containing 6-O-alkylguanosines
Roelen, H. C. P. F.,Brugghe, H. F.,Elst, H. van den,Klein, J. C.,Marel, G. A. van der,Boom, J. H. van
, p. 227 - 234 (2007/10/02)
High-quality oligodeoxynucleotides having an 6-O-alkyl-2'-deoxyguanosine (alkyl = methyl, ethyl, n-propyl or n-hexyl) residue at a predetermined position can be obtained via a solid-phase approach using the respective 2-cyanoethyl N,N-diisopropylphosphoramidites of 5'-O-(4,4'-dimethoxytrityl)-protected 6-O-alkyl-2'-deoxyguanosines having a free exocyclic amino group, and 5'-O-(4,4'-dimethoxytrityl) N-acyl-protected (i.e., benzoyl and isobutyryl for dC, dA and dG, respectively) 2'-deoxynucleosides.