142784-23-4

Basic information

• Product Name: 2-Propen-1-one, 1,3-bis(3-hydroxyphenyl)-, (2E)-
• CAS NO: 142784-23-4
• Molecular Formula: C15H12O3
• Molecular Weight: 240.258
• Mol File: 142784-23-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1,3-bis(3-hydroxyphenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1,3-bis(3-hydroxyphenyl)-, (2E)-(142784-23-4)
• EPA Substance Registry System: 2-Propen-1-one, 1,3-bis(3-hydroxyphenyl)-, (2E)-(142784-23-4)

Safety Data

• Hazardous Substances Data: 142784-23-4(Hazardous Substances Data)

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 100-83-4 meta-hydroxybenzaldehyde 
• 114590-73-7 1-(3-isopropoxyphenyl)ethanone 

Downstream Products

• 1448510-02-8 1,3-bis(4-((4-chlorophenyl)diazenyl)-3-hydroxyphenyl)prop-2-en-1-one 
• 1362510-76-6 3,3′-(6-phenylpyridine-2,4-diyl)diphenol 
• 1070733-32-2 C₂₁H₁₇NO₂S 

Relevant articles and documents

Biological evaluation and synthesis of new pyrimidine-2(1H)-ol/-thiol derivatives derived from chalcones using the solid phase microwave method

Twenty-five new hydroxy- and methoxy-substituted 4,6-diarylpyrimidin-2(1H)-ol (20–34) and 4,6-diarylpyri-midine-2(1H)-thiol derivatives (35–44) were synthesized from the reaction of the corresponding 1,3-diaryl-2-propene-1-one compounds (1–19) with urea or thiourea using the solid-phase microwave method. All the new synthetic compounds (20–44) were evaluated with regard to their α-glucosidase activity. However, only compounds 22–25, 27, 31, 34, 35, 37, and 40 exhibited a greater inhibitory effect than standard acarbose. The IC50 values of the active compounds ranged between 2.36 and 13.34 μM. The 25 new compounds were also screened for their in vitro pancreatic lipase activity and compounds 20–27 and 35–39 were found to be active. Of these compounds 26, 27, and 39 exhibited the best antilipase activities at concentrations of 0.40 ± 0.06, 0.26 ± 0.07, and 0.29 ± 0.026 μM. All the new compounds (20–44) were evaluated for their in vitro antimicrobial activity for nine test microorganisms. Compounds 20–24 and 35–39 were determined to possess a significant broad spectrum against the gram-positive bacteria Escherichia faecalis, Staphylococcus aureus, and Bacillus cereus among the tested bacterial agents. Compounds 20–24 and 35–39 exhibit the best activity against Mycobacterium smegmatis, with minimum inhibitory concentrations of 62.5–500 μg/mL, indicating their potential use as antituberculous agents.

Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison

Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kr?hnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups

Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor

We describe our rationale for designing specific catalytic inhibitors of topoisomerase II (topo II) over topoisomerase I (topo I). Based on 3D-QSAR studies of previously published dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives, 9 novel dihydroxyl