114590-73-7

Basic information

• Product Name: CHEMBRDG-BB 4303055
• Synonyms: CHEMBRDG-BB 4303055;1-(3-Isopropoxyphenyl)ethanone;1-(3-isopropoxyphenyl)ethanone(SALTDATA: FREE);1-(3-propan-2-yloxyphenyl)ethanone;IVK/9041226
• CAS NO: 114590-73-7
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 114590-73-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 256.5°C at 760 mmHg
• Flash Point: 101.3°C
• Appearance: /
• Density: 0.999g/cm³
• Vapor Pressure: 0.0153mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: CHEMBRDG-BB 4303055(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 4303055(114590-73-7)
• EPA Substance Registry System: CHEMBRDG-BB 4303055(114590-73-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 114590-73-7(Hazardous Substances Data)

Usage

General Description

CHEMBRDG-BB 4303055 is a chemical compound with the molecular formula C13H14ClFN2O2. It is a potential inhibitor of the protein kinase C (PKC) enzyme, which plays a crucial role in various cellular processes, including signal transduction and cell proliferation. Studies have shown that inhibition of PKC can lead to therapeutic effects in the treatment of various diseases, including cancer and inflammatory conditions. CHEMBRDG-BB 4303055 has shown promise as a novel compound for the development of potential PKC inhibitors for the treatment of these diseases.

InChI:InChI=1/C11H14O2/c1-8(2)13-11-6-4-5-10(7-11)9(3)12/h4-8H,1-3H3

Upstream product

• 75-30-9 2-iodo-propane 
• 121-71-1 3-Hydroxyacetophenone 
• 75-26-3 isopropyl bromide 

Downstream Products

• 114590-68-0 3-isopropyloxybenzoylacetic acid 
• 114590-65-7 3',7-dihydroxyneoflavone 
• 114590-71-5 7-hydroxy-3'-isopropyloxyneoflavone 
• 142784-23-4 (E)-1-(3-hydroxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one 
• 108997-29-1 (E)-1-(3-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 3033-92-9 (E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 38270-24-5 3-(2-hydroxyphenyl)-1-(3-hydroxyphenyl)-2-propen-1-one 
• 892871-92-0 C₁₈H₁₈O₂ 
• 3033-92-9 1-(3-hydroxyphenyl)-3-phenyl-2-propen-1-one 
• 1198745-10-6 1-{3-[(1-methylethyl)oxy]phenyl}-2-{[4-(3-{[(methyloxy)methyl]oxy} isoxazol-5-yl)phenyl]oxy}ethanone 
• 1198745-21-9 5-(4-{[1-(3-isopropoxyphenyl)ethoxy]methyl}phenyl)-3-(methoxymethoxy)isoxazole 
• 1198745-12-8 5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole 
• 1198745-11-7 1-{3-[(1-methylethyl)oxy]phenyl}-2-{[4-(3-{[(methyloxy)methyl]oxy}isoxazol-5-yl)phenyl]oxy}ethanol 

Relevant articles and documents

Pyrrolidine integrin regulator and application thereof

Disclosed are a compound as represented by formula I, and a racemate, a stereoisomer, a tautomer, an isotopic marker, a nitrogen oxide, a solvate, a polymorph, a metabolite, an ester, and a prodrug thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same, a preparation method therefor, and the medical use thereof. The structure of formula I is as follows:

Chalcone derivatives enhance ATP-binding cassette transporters A1 in human THP-1 macrophages

Atherosclerosis is a process of imbalanced lipid metabolism in the vascular walls. The underlying pathology mainly involves the deposition of oxidized lipids in the endothelium and the accumulation of cholesterol in macrophages. Macrophages export excessive cholesterol (cholesterol efflux) through ATP-binding cassette transporter A1 (ABCA1) to counter the progression of atherosclerosis. We synthesized novel chalcone derivatives and assessed their effects and the underlying mechanisms on ABCA1 expression in macrophages. Human THP-1 macrophages were treated with synthetic chalcone derivatives for 24 h. In Western blot and flow cytometry analyses, a chalcone derivative, (E)-1-(3,4-diisopropoxyphenyl)-3-(4-isopropoxy-3-methoxyphenyl)prop- 2-en-1-one (1m), was observed to significantly enhance ABCA1 protein expression in THP-1 cells (10 μM, 24 h). Levels of mRNA of ABCA1 and liver X receptor alpha (LXRα) were quantified using a real-time quantitative polymerase chain reaction technique and were found to be significantly increased after treatment with the novel chalcone derivative 1m. Several microRNAs, including miR155, miR758, miR10b, miR145, miR33, and miR106b, which functionally inhibit ABCA1 expression were suppressed after treatment with 1m. Collectively, 1m increases ABCA1 expression in human THP-1 macrophages. The mechanisms involve the activation of the LXRα-ABCA1 pathway and suppression of certain microRNAs that regulate ABCA1 expression.

TETRAZOLINONE COMPOUND AND USE THEREOF

The compound represented by formula (1): wherein R4 and R5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R7, R8, and R9 each represents a hydrogen atom, a halogen atom, or the like; R10 represents a C1-C3 alkyl group, or the like; R13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.