143-62-4Relevant articles and documents
Gvazava
, (1977)
THERMAL TRANSFORMATION OF CARDIAC GLYCOSIDES II. ACIDLESS HYDROLYSIS OF LABILE GLYCOSIDES IN AQUEOUS ALCOHOLIC SOLUTIONS AND PROSPECTS FOR ITS UTILIZATION
Makarevich, I. F.,Tishchenko, A. A.,Terno, I. S.
, p. 53 - 55 (1991)
The thermal transformations of cardiac glycosides in neutral alcoholic solutions have been investigated.The kinetics of their acidless hydrolysis at 100 and 142 deg C and the activation energy of the process have been studied.The possibility has been shown of the stepwise hydrolysis of natural trisdigitoxosides with the production of difficulty available mono- and bisdigitoxosides.The following were used as the objects of investigation: convallatoxin, glucostrophanthidin, cheirotoxin, desglucocheirotoxin, erycordin, erysimin, erysimoside, digitoxin, and cymarin.
Goutarel et al.
, p. 297,300 (1972)
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Stoll,Kreis
, (1935)
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Stoll,Kreis
, (1935)
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Makarevich et al.
, (1975)
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Ponomarenko et al.
, (1971)
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Assembly of digitoxin by gold(I)-catalyzed glycosidation of glycosyl o-alkynylbenzoates
Ma, Yuyong,Li, Zhongzhen,Shi, Hefang,Zhang, Jian,Yu, Biao
body text, p. 9748 - 9756 (2012/01/04)
Digitoxin, a clinically important cardiac trisaccharide, was assembled efficiently from digitoxigenin and 3,4-di-O-tert-butyldiphenylsilyl-d- digitoxosyl o-cyclopropylethynylbenzoate in 9 steps and 52% overall yield via alternate glycosylation and protecting group manipulation. The present synthesis showcases the advantage of the gold(I)-catalyzed glycosylation protocol in the synthesis of glycoconjugates containing acid-labile 2-deoxysugar linkages.
GLYCOSIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
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Page/Page column 22, (2010/04/03)
The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.