143022-93-9

Basic information

• Product Name: (1R,2R,4S,5S)-4-<(2R)-2-chloropropanoyloxy>bicyclo<3.1.0>hexan-2-ol
• Synonyms: (1R,2R,4S,5S)-4-<(2R)-2-chloropropanoyloxy>bicyclo<3.1.0>hexan-2-ol
• CAS NO: 143022-93-9
• Molecular Weight: 204.653
• Mol File: 143022-93-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R,4S,5S)-4-<(2R)-2-chloropropanoyloxy>bicyclo<3.1.0>hexan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R,4S,5S)-4-<(2R)-2-chloropropanoyloxy>bicyclo<3.1.0>hexan-2-ol(143022-93-9)
• EPA Substance Registry System: (1R,2R,4S,5S)-4-<(2R)-2-chloropropanoyloxy>bicyclo<3.1.0>hexan-2-ol(143022-93-9)

Safety Data

• Hazardous Substances Data: 143022-93-9(Hazardous Substances Data)

Upstream product

• 7474-05-7 (R)-2-chloropropionic acid 
• 137726-46-6 (1RS,2RS,4SR,5SR)-Bicyclo<3.1.0>hexane-2,4-diol 

Relevant articles and documents

Double Enantioselective Transesterification of Racemic Carboxylic Esters and Cycil meso-Diols by Lipase Catalysis

Lipase-catalysed double enantioselective transesterifications of racemic carboxylic esters and cyclic meso-diols to give the hydroxy esters 3, 6, 9, 11 and 14 have been investigated.The selectivity of this process is determined by the structure of both substrates and the origin of the lipase.In four of the five cases investigated, lipase SP 382 shows the highest activity and selectivity.In the products, excepting the acyl part of compounds 3, (S)-selectivity for both the alcohol and the acyl mojety has been observed.However, regarding the acyl part the selectivity is poor compared with that of the alcohol part.Application of this method allows us to prepare enantiomerically pure compounds with at least three asymmetric centres in one biocatalytic step if the reaction partners are matching and/or the products are easy to separate as found for compounds 9a, 9c and 11a for instance. the X-ray molecular strucutres of compounds 9a and 11a are reported.