7474-05-7Relevant articles and documents
Preparation method of D-2-chloropropionyl chloride and D-2-chloropropionyl chloride
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Paragraph 0055; 0058-0059; 0065; 0068-0069; 0076; 0079-0080, (2021/03/13)
The invention is applicable to the technical field of synthesis of medical intermediates, and provides a preparation method of D-2-chloropropionyl chloride and D-2-chloropropionyl chloride, the preparation method comprises the following steps: adding L-ethyl lactate and a catalyst into a reaction vessel, dropwisely adding thionyl chloride at -10-10 DEG C, heating to 65-70 DEG C, and carrying out heat preservation reaction; after the reaction is finished, cooling to 10-30 DEG C, and carrying out reduced pressure concentration and other treatment to obtain ethyl D-2-chloropropionate; adding resin, anhydrous formic acid and water, heating to 70-100 DEG C, and reacting for 2-5 hours; after the reaction is finished, cooling to 10-30 DEG C, filtering, and distilling to obtain D-2-chloropropionicacid; and dropwise adding thionyl chloride at 0-5 DEG C, heating to 45-65 DEG C, carrying out heat preservation reaction, and carrying out vacuum concentration and distillation treatment to obtain the product. The method realizes 10kg-grade large-scale production of D-2-chloropropionyl chloride, and has the advantages of high yield, high purity, recyclable catalyst, and no need of rectification equipment.
Method for synthesizing (R)-2-chloropropionic acid by solid acid catalysis and trans-esterification reaction based on UIO-66
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Paragraph 0010; 0012; 0014, (2017/07/20)
The invention provides a method for synthesizing (R)-2-chloropropionic acid by a solid acid catalysis and trans-esterification reaction based on UIO-66. The method comprises the following steps: (1) preparation of a solid acid catalyst SO4/UIO-66; and (2) preparation of (R)-2-chloropropionic acid. According to the method, UIO-66 is adopted as a solid acid catalyst of a substrate, the catalyst has strong acidity, so that the catalyst can effectively catalyze the trans-esterification reaction for synthesizing (R)-2-chloropropionic acid, the transformation rate is higher than 98%, side effects are less, and the catalyst can be used repeatedly, and therefore, the generation of tailings is effectively avoided, the production cost is lowered, and environmental protection is facilitated.
COMPOUNDS FOR USE IN THE TREATMENT OF INFECTIOUS DISEASES
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Page/Page column 59-60, (2016/05/02)
The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.