14316-14-4

Basic information

• Product Name: N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide
• Synonyms: N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide;N-(2-Hydroxyethyl)-4-toluenesulfonaMide
• CAS NO: 14316-14-4
• Molecular Formula: C₉H₁₃NO₃S
• Molecular Weight: 215.26942
• Product Categories: Aromatics;Sulfur & Selenium Compounds
• Mol File: 14316-14-4.mol
• Article Data: 54

Chemical Properties

• Melting Point: 55-57°C
• Boiling Point: 380.2 °C at 760 mmHg
• Flash Point: 183.8 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 1.85E-06mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide(14316-14-4)
• EPA Substance Registry System: N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide(14316-14-4)

Safety Data

• Hazardous Substances Data: 14316-14-4(Hazardous Substances Data)

Usage

Description

N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide, with the CAS number 14316-14-4, is an organic compound that is characterized by its off-white solid appearance. It is primarily recognized for its utility in the field of organic synthesis, where it serves as a valuable intermediate or reagent.

Uses

Used in Organic Synthesis:
N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide is used as a synthetic building block for the creation of various organic compounds. Its unique chemical structure allows it to participate in a range of reactions, facilitating the synthesis of complex molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide is used as an intermediate in the development of new drugs. Its chemical properties make it a suitable candidate for the synthesis of active pharmaceutical ingredients, potentially leading to the discovery of novel therapeutic agents.
Used in Chemical Research:
N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide is also utilized in chemical research as a model compound to study various reaction mechanisms and to develop new synthetic methodologies. Its reactivity and structural features provide valuable insights into the behavior of similar compounds, contributing to the advancement of chemical science.
Used in Material Science:
In the field of material science, N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide may be employed as a component in the development of new materials with specific properties. Its integration into polymers or other materials could lead to the creation of innovative products with applications in various sectors, such as electronics, coatings, or adhesives.

InChI:InChI=1/C9H13NO3S/c1-8-2-4-9(5-3-8)14(12,13)10-6-7-11/h2-5,10-11H,6-7H2,1H3

Upstream product

• 75-21-8 oxirane 
• 70-55-3 toluene-4-sulfonamide 
• 141-43-5 ethanolamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 29981-92-8 1-tosyl-3-methyl-imidazolium chloride 
• 51060-12-9 1-tosyl-2,3-dimethylimidazolium chloride 
• 64-17-5 ethanol 
• 2232-08-8 N-tosylimidazole 
• 107-07-3 2-chloro-ethanol 
• 98-09-9 benzenesulfonyl chloride 
• 51010-88-9 methyl (2E,4E)-6-bromo-2,4-hexadienoate 
• 202974-92-3 N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-benzenesulfonamide 
• 104-15-4 toluene-4-sulfonic acid 
• 107-09-5 2-bromoethylamine 

Downstream Products

• 56643-21-1 N-(2-hydroxy-ethyl)-N-[3-(2-oxo-oxazolidin-3-yl)-propyl]-toluene-4-sulfonamide 
• 50977-94-1 N,N'-di(para-toluensulfonyl)-3,9-diaza-6-oxaundecane-1,11-diol 
• 142639-41-6 3,9,12,18-Tetra(toluene-p-sulfonyl)-6,15-dioxa-3,9,12,18-tetraazaicosane-1,20-diol 
• 1006726-12-0 N-(2-pivaloyloxyethyl)-p-toluenesulfonamide 
• 1006726-13-1 N-(2-benzoyloxyethyl)-p-toluenesulfonamide 
• 1020203-73-9 C₁₆H₂₂N₂O₄S 
• 869275-29-6 N-allyl-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide 
• 70509-21-6 2-phenyl-3-tosyloxazolidine 
• 1160723-39-6 N-(2-hydroxyethyl)-4-methyl-N-(phenylethynyl)benzenesulfonamide 
• 152877-88-8 C₁₃H₁₇NO₃S 
• 152877-94-6 C₁₃H₁₇NO₃S 
• 1268631-08-8 C₂₃H₃₅NO₆S 
• 1268631-09-9 C₂₄H₄₁NO₅SSi 
• 1268631-20-4 C₂₀H₃₅NO₄SSi 

Relevant articles and documents

Synthesis and crystal structures of multifunctional tosylates as basis for star-shaped poly(2-ethyl-2-oxazoline)s

The synthesis of well-defined polymer architectures is of major importance for the development of complex functional materials. In this contribution, we discuss the synthesis of a range of multifunctional star-shaped tosylates as potential initiators for the living cationic ring-opening polymerization (CROP) of 2-oxazolines resulting in star-shaped polymers. The synthesis of the tosylates was performed by esterification of the corresponding alcohols with tosyl chloride. Recrystallization of these tosylate compounds afforded single crystals, and the X-ray crystal structures of di-, tetra-and hexa-tosylates are reported. The use of tetra-and hexatosylates, based on (di)pentaerythritol as initiators for the CROP of 2-ethyl-2-oxazoline, resulted in very slow initiation and illdefined polymers, which is most likely caused by steric hindrance in these initiators. As a consequence, a porphyrin-cored tetratosylate initiator was prepared, which yielded a well-defined star-shaped poly(2-ethyl-2-oxazoline) by CROP as demonstrated by SEC with RI, UV and diode-array detectors, as well as by 1H NMR spectroscopy.

Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications

Herein we report a catalyst- and metal-free visible-light-mediated protocol enabling the iodoamination of miscellaneous olefins. This protocol is characterized by high yields under environmentally benign reaction conditions utilizing commercially available substrates and a green and biodegradable solvent. Furthermore, the protocol allows for late-stage functionalization of bioactive molecules and can be scaled to gram quantities of product, which offers manifold possibilities for further transformations, including morpholine, piperidine, pyrrolidine, and aziridine synthesis.

Enantio- and Regioselective Palladium(II)-Catalyzed Dioxygenation of (Aza-)Alkenols

An oxidative Pd-catalyzed intra-intermolecular dioxygenation of (aza-)alkenols has been reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent-iodine compounds have been compared. I