143262-20-8 Usage
Description
N-Boc-indoline-7-carboxylic acid, also known as 1-(tert-butoxycarbonyl)indoline-7-carboxylic acid, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and natural products. It is characterized by its off-white solid appearance and plays a significant role in the development of potent and selective EP4 receptor ligands.
Uses
Used in Pharmaceutical Industry:
N-Boc-indoline-7-carboxylic acid is used as a reagent for the preparation of potent and selective EP4 receptor ligands. These ligands are essential in the development of drugs targeting the EP4 receptor, which is involved in various physiological processes, including inflammation and pain regulation.
Used in Natural Product Synthesis:
N-Boc-indoline-7-carboxylic acid is used as a useful starter in indoline-based natural product synthesis. Indolines are a class of organic compounds that are found in many natural products with diverse biological activities. This acid serves as a key building block in the synthesis of these complex molecules, contributing to the development of novel therapeutic agents.
Used in Chemical Research:
As an off-white solid, N-Boc-indoline-7-carboxylic acid is also utilized in chemical research for the study of its properties and potential applications in various fields. Researchers can explore its reactivity, stability, and other characteristics to develop new synthetic routes and applications in the chemical and pharmaceutical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 143262-20-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,2,6 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 143262-20:
(8*1)+(7*4)+(6*3)+(5*2)+(4*6)+(3*2)+(2*2)+(1*0)=98
98 % 10 = 8
So 143262-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H17NO4/c1-14(2,3)19-13(18)15-8-7-9-5-4-6-10(11(9)15)12(16)17/h4-6H,7-8H2,1-3H3,(H,16,17)
143262-20-8Relevant articles and documents
A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism
Boyd, Michael J.,Berthelette, Carl,Chiasson, Jean-Franois,Clark, Patsy,Colucci, John,Denis, Danielle,Han, Yongxin,Lévesque, Jean-Francois,Mathieu, Marie-Claude,Stocco, Rino,Therien, Alex,Rowland, Steve,Wrona, Mark,Xu, Daigen
scheme or table, p. 484 - 487 (2011/02/27)
A novel series of EP4 ligands, based on a benzyl indoline scaffold, has been discovered. It was found that agonism and antagonism in this series can be easily modulated by minor modifications on the benzyl group. The pharmacokinetic, metabolic
INDOLINE AMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS
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Page/Page column 21, (2008/06/13)
The invention is directed to indoline amide derivatives as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and gla
DIRECTED LITHIATION OF 1-(tert-BUTOXYCARBONYL)INDOLINES. A CONVENIENT ROUTE TO 7-SUBSTITUTED INDOLINES
Iwao, Masatomo,Kuraishi, Tsukasa
, p. 1031 - 1038 (2007/10/02)
1-(tert-Butoxycarbonyl)indolines were regioselectively lithiated at 7-position with s-BuLi-TMEDA in ether or THF at -78 deg C.The lithiated species were reacted with a range of electrophiles to give 7-substituted indoline derivatives.
