112106-91-9

Basic information

• Product Name: 1H-INDOLE-7-CARBOXYLIC ACID,2,3-DIHYDRO-,METHYL ESTER
• Synonyms: 1H-INDOLE-7-CARBOXYLIC ACID,2,3-DIHYDRO-,METHYL ESTER;Methyl indoline-7-carboxylate;Indoline-7-Carbocylic acid methyl ester;Indoline-7-carboxylic acid methyl ester;2,3-Dihydro-1H-indole-7-carboxylic acid methyl ester
• CAS NO: 112106-91-9
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 112106-91-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 69-69.5 °C
• Boiling Point: 328.4±31.0 °C(Predicted)
• Appearance: /
• Density: 1.162±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.04±0.20(Predicted)
• CAS DataBase Reference: 1H-INDOLE-7-CARBOXYLIC ACID,2,3-DIHYDRO-,METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE-7-CARBOXYLIC ACID,2,3-DIHYDRO-,METHYL ESTER(112106-91-9)
• EPA Substance Registry System: 1H-INDOLE-7-CARBOXYLIC ACID,2,3-DIHYDRO-,METHYL ESTER(112106-91-9)

Safety Data

• Hazardous Substances Data: 112106-91-9(Hazardous Substances Data)

Usage

General Description

1H-Indole-7-carboxylic acid, 2,3-dihydro-, methyl ester is a chemical compound that is derived from indole, a heterocyclic organic compound. It is commonly used in the pharmaceutical and chemical industries for the synthesis of various pharmaceutical drugs and therapeutic agents. 1H-INDOLE-7-CARBOXYLIC ACID,2,3-DIHYDRO-,METHYL ESTER is a methyl ester, which means it contains a methyl group attached to the carboxylic acid functional group. It can react with other chemicals to form new compounds with potential biological activities. As a result, it is considered to be a valuable building block for the production of new drugs and compounds with potential therapeutic applications. However, it is important to handle this compound with care and follow safety guidelines, as it may have hazardous properties.

Upstream product

• 186581-53-3 diazomethane 
• 201230-82-2 carbon monoxide 
• 197460-40-5 1-(1,1-dimethylethyl) 7-methyl 2,3-dihydro-1H-indole-1,7-dicarboxylate 
• 143262-20-8 1-(tert-butoxycarbonyl)indoline-7-carboxylic acid 
• 93247-78-0 methyl 1H-indole-7-carboxylate 

Relevant articles and documents

HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38

The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.

A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments

An efficient hydrogenation protocol under continuous flow conditions was developed for the synthesis of underrepresented semi-saturated bicyclic fragments containing highly sp3-rich skeletons for fragment-based drug discovery (FBDD) programs. Excellent yields were generally achieved by using Pd/C (10 % w/w) and RaNi at 25–150 °C under 4–100 bar of hydrogen pressure. The generated fragments, with appropriate physicochemical properties, present diverse hydrogen-bonding pharmacophores and useful vectors for their synthetic elaboration in the optimization stage. Successive, simple functionalizations in continuous flow were accomplished to demonstrate the opportunity to develop multi-step continuous flow synthesis of valuable starting points for FBDD campaigns. A conclusive quality control (QC) was essential to discard those structures which do not fit the typical fragment library parameters.

A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

A novel series of EP4 ligands, based on a benzyl indoline scaffold, has been discovered. It was found that agonism and antagonism in this series can be easily modulated by minor modifications on the benzyl group. The pharmacokinetic, metabolic