14347-05-8

Basic information

• Product Name: 4-Benzyloxy-3-nitroacetophenone
• Synonyms: 4'-Benzyloxy-3'-nitroacetophenone;4-Benzyloxy-3-nitroacetophenone ,98%;Ethanone, 1-[3-nitro-4-(phenylMethoxy)phenyl]-;1-[4-PhenylMethoxy-3-nitrophenyl]ethanone;4-benzyloxy-3-nitroacetophenone, 1-[4-Phenylmethoxy-3-nitrophenyl]ethanone, 3-nitro-4-benzyloxyacetophenone, 1-(4-(benzyloxy)-3-nitrophenyl)ethan-1-one, 1-(4-(benzyloxy)-3-nitrophenyl)ethanone, 1-(4-benzyloxy-3-nitrophenyl)ethanone, 3-nitro-4-benzilossiacetofenone;4'-BENZYLOXY-3'-NITROACETOPHENONE;4-BENZYLOXY-3-NITRO-ACETOPHENONE;1-[3-nitro-4-(phenylmethoxy)phenyl]ethanone
• CAS NO: 14347-05-8
• Molecular Formula: C₁₅H₁₃NO₄
• Molecular Weight: 271.27
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);(intermediate of formoterol);Aromatics
• Mol File: 14347-05-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 134-136 °C(Solv: acetone (67-64-1))
• Boiling Point: 426.6 °C at 760 mmHg
• Flash Point: 184.6 °C
• Appearance: yellow solid
• Density: 1.247 g/cm₃
• Vapor Pressure: 1.75E-07mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility: Chloroform, DMF, DMSO, Ethyl Acetate
• CAS DataBase Reference: 4-Benzyloxy-3-nitroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyloxy-3-nitroacetophenone(14347-05-8)
• EPA Substance Registry System: 4-Benzyloxy-3-nitroacetophenone(14347-05-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 14347-05-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

InChI:InChI=1/C15H13NO4/c1-11(17)13-7-8-15(14(9-13)16(18)19)20-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3

Upstream product

• 400-93-1 3-nitro-4-fluoroacetophenone 
• 100-51-6 benzyl alcohol 
• 6322-56-1 4'-hydroxy-3'-nitroacetophenone 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 99-93-4 4-Hydroxyacetophenone 
• 515152-69-9 2-benzyloxy-5-vinylnitrobenzene 
• 54696-05-8 4'-benzyloxy-acetophenone 

Downstream Products

• 61560-90-5 2-(3-nitro-4-benzyloxyphenyl)glyoxylic acid 
• 43229-01-2 4-benzyloxy-3-nitrophenacyl bromide 
• 14347-15-0 1-[4-phenylmethoxy-3-aminophenyl]ethanone 
• 299964-35-5 (+/-)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol 
• 188730-94-1 (R)-1-(4-benzyloxy-3-nitrophenyl)oxirane 
• 188730-96-3 (S)-4-benzyloxy-3-nitrostyrene oxide 
• 188690-82-6 (R)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol 
• 73573-87-2 (R,R)-formoterol 
• 299964-37-7 Acetic acid (S)-1-(4-benzyloxy-3-nitro-phenyl)-2-bromo-ethyl ester 
• 299964-43-5 (R)-1-(3-Amino-4-benzyloxy-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol 
• 245759-61-9 (R)-1-(4-Benzyloxy-3-nitro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol 
• 408497-91-6 N-(2-Benzyloxy-5-{(R)-1-hydroxy-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-formamide 
• 51582-41-3 2-(3-benzyloxy-4-nitrophenyl)oxirane 
• 61560-98-3 (4-hydroxy-3-nitro-phenyl)-glyoxylic acid 

Relevant articles and documents

An Intermediate in the Synthesis of Formoterol

In the title compound, 4-benzyloxy-3-nitrophenacyl bromide, C15H12BrNO4, the two planar nitrophenyl and benzyloxy groups are inclined at a dihedral angle of 17.1(1) deg.The NO2 group is twisted out of the plane of the phenyl ring by 20.4(3) deg to minimize steric hindrance between O(4) and O(3); the O(4)...O(3) separation is 2.600(5) Angstroem and the angle O(4)...O(3)-N(1) is 88.2(4) deg.

Preparation method of 3-nitro-4-benzyloxy-2-bromoacetophenone

The invention relates to a preparation method of 3-nitro-4-benzyloxy-2-bromoacetophenone. Particularly, 3-nitro-4-hydroxyacetophenone and benzyl bromide are taken as raw materials, and 3-nitro-4-benzyloxy-2-bromoacetophenone is synthesized through hydroxy protection and trimethylphenylammonium tribromide bromination reaction in a high-yield manner. The preparation method of 3-nitro-4-benzyloxy-2-bromoacetophenone in the synthesis route is high in yield, low in cost, easy to operate and suitable for industrialization.

Method forsynthesizing ketone by oxidation of alkene under catalysis of iron

The invention discloses a method for synthesizing ketoneby oxidation of alkene under catalysis of iron, and belongs to the field of catalyzed synthesis technologies and fine chemical synthesis. According to the specific method, air or oxygen is taken as an oxidizing agent under the acceleration action ofhydrosilaneand a ketone compound is synthesized byoxidation of alkene under catalysis of iron. The method has the advantages that the catalyst is wide in source, cheap and environment-friendly; the oxidant is wide in source and cheap and does not generate a waste; the reaction conditions are mild, the selectivity is high and the yield is high;a substrate is wide and stable; a functional group of the substrate is good in compatibility and the application range of the substrate is wide; and alkene molecules can be well converted into the ketone. The separation yield of a target product reaches 98% under the optimized reaction conditions.

COMPOUNDS, IN PARTICULAR FOR USE IN THE TREATMENT OF A DISEASE OR CONDITION FOR WHICH A BROMODOMAIN INHIBITOR IS INDICATED

The invention relates to a compound for use in the treatment of a disease or condition for which a bromodomain inhibitor is indicated characterized by a general formula (1) and a compound according to formula (3).