51582-41-3

Basic information

• Product Name: [3-Nitro-4-(phenylmethoxy)phenyl]-oxirane
• Synonyms: 4-BENZYLOXY-3-NITROSTYRENOXIDE;4-benzyloxy-1-(epoxyethyl)-3-nitrobenzene;[3-nitro-4-(phenylmethoxy)phenyl]-oxirane;4-Benzyloxy-3-Nitro-Styrenoxide(ForFormoterolFumarate);forFormoterolfumarate;2-[3-Nitro-4-(phenylMethoxy)phenyl]oxirane
• CAS NO: 51582-41-3
• Molecular Formula: C₁₅H₁₃NO₄
• Molecular Weight: 271.27
• Product Categories: (intermediate of formoterol fumarate);Aromatics
• Mol File: 51582-41-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 71-73°C
• Boiling Point: 438.502 °C at 760 mmHg
• Flash Point: 195.617 °C
• Appearance: yellow solid
• Density: 1.323
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: [3-Nitro-4-(phenylmethoxy)phenyl]-oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: [3-Nitro-4-(phenylmethoxy)phenyl]-oxirane(51582-41-3)
• EPA Substance Registry System: [3-Nitro-4-(phenylmethoxy)phenyl]-oxirane(51582-41-3)

Safety Data

• Hazardous Substances Data: 51582-41-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

InChI:InChI=1/C15H13NO4/c17-16(18)13-8-12(15-10-20-15)6-7-14(13)19-9-11-4-2-1-3-5-11/h1-8,15H,9-10H2

Upstream product

• 299964-35-5 (+/-)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol 
• 99-93-4 4-Hydroxyacetophenone 
• 14347-05-8 4-benzyloxy-3-nitroacetophenone 
• 6322-56-1 4'-hydroxy-3'-nitroacetophenone 
• 43229-01-2 4-benzyloxy-3-nitrophenacyl bromide 

Downstream Products

• 128954-45-0 formoterol 
• 169375-55-7 formoterol fumarate 
• 43229-67-0 1-(4-benzyloxy-3-nitrobenzene)-2-{benzyl-[2-(4-methoxyphenyl)-1-methylethyl]amino}ethanol 
• 1068147-87-4 tert-butyl 6-(benzyl(2-(4-(benzyloxy)-3-nitrophenyl)hydroxyethyl)amino)hexylcarbamate 
• 1068147-86-3 tert-butyl 4-(benzyl(2-(4-(benzyloxy)-3-nitrophenyl)hydroxyethyl)amino)butylcarbamate 
• 1068147-85-2 tert-butyl 2-(benzyl(2-(4-(benzyloxy)-3-nitrophenyl)hydroxyethyl)amino)ethylcarbamate 
• 1068147-88-5 tert-butyl 2-(2-(2-(benzyl(2-(4-(benzyloxy)-3-nitrophenyl)hydroxyethyl)amino)ethoxy)ethoxy)ethylcarbamate 
• 876753-53-6 N-(2-benzyloxy-5-vinylphenyl)formamide 
• 515152-69-9 2-benzyloxy-5-vinylnitrobenzene 
• 876753-52-5 2-benzyloxy-5-vinylaniline 
• 1028681-14-2 C₃₁⁽¹³⁾CH₂₅⁽²⁾H₉N₂O₅ 

Relevant articles and documents

Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)-phenyl]formamide: Formal synthesis of formoterol

Nitration, benzylation followed by bromination of 4- hydroxyacetophenone is described to obtain nitrobenzyloxyphenacyl bromide derivative 3. Sodiumborohydride reduction of 3 gives rise to the diol 6. Reaction of 6 with Ph3P/I2/imidaz

Bronchospasmolytic phenylethanolamines

Phenylethanolamines of the formula I STR1 wherein R is substituted phenyl or optionally substituted furyl, thienyl, or pyridyl, R5 is hydrogen, lower alkyl, or optionally substituted benzyl, R4, R6, R8, and Rsu