1435347-65-1

Basic information

• Product Name: C₁₂H₁₁AuCl₃N₂⁽¹⁺⁾*Cl^(1-)
• Synonyms: C₁₂H₁₁AuCl₃N₂⁽¹⁺⁾*Cl^(1-)
• CAS NO: 1435347-65-1
• Molecular Weight: 522.011
• Mol File: 1435347-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₁AuCl₃N₂⁽¹⁺⁾*Cl^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₁AuCl₃N₂⁽¹⁺⁾*Cl^(1-)(1435347-65-1)
• EPA Substance Registry System: C₁₂H₁₁AuCl₃N₂⁽¹⁺⁾*Cl^(1-)(1435347-65-1)

Safety Data

• Hazardous Substances Data: 1435347-65-1(Hazardous Substances Data)

Upstream product

• 27048-28-8 4-chloro-N-(pyridin-2-ylmethyl)aniline 

Relevant articles and documents

Synthesis and evaluation of gold(III) complexes as efficient DNA binders and cytotoxic agents

In recent years, great interest has been focused on gold(III) complexes as cytotoxic and antitumor drugs. Recent studies demonstrated that simple bidentate or polydentate ligands containing nitrogen donor atoms may offer sufficient redox stabilization to produce viable Au(III) anticancer drug targets under physiologic conditions. So, we have synthesized square planer Au(III) complexes of type [Au(An)Clx]Cly and characterized them using UV-Vis absorption, C, H, N elemental analysis, FT-IR, LC-MS, 1H and 13C NMR spectroscopy. These compounds manifested significant cytotoxic properties in vitro for brine shrimp lethality bioassay. The metal complexes were screened for series of DNA binding activity using UV-Vis absorption titration, hydrodynamic measurement and thermal DNA denaturation study. The nucleolytic activity was performed on plasmid pUC19 DNA. The Michaelis-Menten kinetic studies were performed to evaluate rate of enhancement in metal complexes mediated DNA cleavage over the non-catalyzed DNA cleavage.