1435517-99-9

Basic information

• Product Name: 1-phenyl-5-(p-tolyl)pent-4-yn-1-one
• Synonyms: 1-phenyl-5-(p-tolyl)pent-4-yn-1-one
• CAS NO: 1435517-99-9
• Molecular Weight: 248.324
• Mol File: 1435517-99-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-phenyl-5-(p-tolyl)pent-4-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-5-(p-tolyl)pent-4-yn-1-one(1435517-99-9)
• EPA Substance Registry System: 1-phenyl-5-(p-tolyl)pent-4-yn-1-one(1435517-99-9)

Safety Data

• Hazardous Substances Data: 1435517-99-9(Hazardous Substances Data)

Upstream product

• 1061175-65-2 5-(p-tolyl)pent-4-ynoic acid methyl ester 
• 766-97-2 4-n-methylphenylacetylene 
• 29526-96-3 1-phenylcyclopropan-1-ol 
• 98-86-2 acetophenone 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 38858-73-0 1-phenyl-1-trimethylsiloxycyclopropane 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 18476-65-8 1-phenylpenta-4-yn-1-one 
• 624-31-7 4-tolyl iodide 
• 152705-37-8 N-methoxy-N-methylpent-4-ynamide 
• 6089-09-4 4-pentynoic acid 

Downstream Products

• 1435518-42-5 3-phenyl-7-(p-tolyl)hepta-1,6-diyn-3-yl benzoate 
• 1435518-17-4 3-phenyl-7-(p-tolyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol 

Relevant articles and documents

Alkyne Trifunctionalization via Divergent Gold Catalysis: Combining π-Acid Activation, Vinyl-Gold Addition, and Redox Catalysis

Here we report the first example of alkyne trifunctionalization through simultaneous construction of C-C, C-O, and C-N bonds via gold catalysis. With the assistance of a γ-keto directing group, sequential gold-catalyzed alkyne hydration, vinyl-gold nucleophilic addition, and gold(III) reductive elimination were achieved in one pot. Diazonium salts were identified as both electrophiles (N source) and oxidants (C source). Vinyl-gold(III) intermediates were revealed as effective nucleophiles toward diazonium, facilitating nucleophilic addition and reductive elimination with high efficiency. The rather comprehensive reaction sequence was achieved with excellent yields (up to 95%) and broad scope (>50 examples) under mild conditions (room temperature or 40 °C).

Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp3)-C(sp3) Bond Cleavage and Functionalizations

The alkoxyl radical is an important reactive intermediate in mechanistic studies and organic synthesis; however, its current generation from alcohol oxidation heavily relies on transition metal activation under strong oxidative conditions. Here we report the first visible-light-induced alcohol oxidation to generate alkoxyl radicals by cyclic iodine(III) reagent catalysis under mild reaction conditions. The β-fragmentation of alkoxyl radicals enables selective C(sp3)-C(sp3) bond cleavage and alkynylation/alkenylation reactions with various strained cycloalkanols, and for the first time with linear alcohols.