1437759-76-6

Basic information

• Product Name: C₂₂H₂₇ClN₂O
• CAS NO: 1437759-76-6
• Molecular Weight: 370.922
• Mol File: 1437759-76-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₇ClN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₇ClN₂O(1437759-76-6)
• EPA Substance Registry System: C₂₂H₂₇ClN₂O(1437759-76-6)

Safety Data

• Hazardous Substances Data: 1437759-76-6(Hazardous Substances Data)

Upstream product

• 1155-56-2 1-benzyl-N-phenylpiperidin-4-amine 
• 7623-11-2 2-chlorobutyryl chloride 

Downstream Products

• 1437759-78-8 C₂₂H₂₆N₂O 

Relevant articles and documents

Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.

The nociceptin receptor (NOP) and its endogenous agonist, nociceptin/orphanin FQ (N/OFQ), members of the opioid receptor and peptide families respectively, modulate the pharmacological effects of classical opioids, particularly opioid-induced reward and nociception. We hypothesized that compounds containing both NOP and opioid receptor activity in a single molecule may have useful pharmacological profiles as non-addicting analgesics or as drug abuse medications. We report here our forays into the structure-activity relationships for discovering 'bifunctional' NOP-mu opioid receptor (MOP) ligands, starting from our NOP-selective scaffolds. This initial SAR suggests pharmacophoric elements that may be modified to modulate/increase opioid affinity, while maintaining high affinity for the NOP receptor, to result in potent bifunctional small-molecule NOP/MOP ligands.