1438279-73-2Relevant articles and documents
A concise synthetic method towards (-)-swainsonine and its 8-epimer by using palladium-catalyzed asymmetric hydroamination of alkoxyallene as the key strategy
Lim, Wontaeck,Rhee, Young Ho
, p. 5939 - 5945 (2015/08/03)
Abstract A concise and flexible formal synthesis of (-)-swainsonine and the 8-epimer is reported. The synthesis features sequential Pd-catalyzed asymmetric hydroamination of alkoxyallene and the Ru-catalyzed ring-closing-metathesis as the key strategy, which generates cyclic allylic N,O-acetal as the pivotal intermediate. Notably, this reaction could be performed on a multigram-scale. In addition, both the natural product and its 8-epimer could be obtained with comparable synthetic efficiency.
Synthetic strategy for cyclic amines: A stereodefined cyclic N,O-acetal as a stereocontrol and diversity-generating element
Kim, Haejin,Lim, Wontaeck,Im, Donghong,Kim, Dong-Gil,Rhee, Young Ho
, p. 12055 - 12058 (2013/01/16)
In control: A new synthetic strategy towards cyclic amines was developed and exploits a stereodefined cyclic N,O-acetal as the key stereocontrol and diversity-generating element. The cyclic N,O-acetal was prepared from the sequential asymmetric hydroamina