14401-61-7 Usage
Description
2,4,5-Tribromophenol is an organic compound with the chemical formula C6H3Br3OH. It is a white crystalline solid that is slightly soluble in water and has a characteristic bromine-like odor. 2,4,5-TRIBROMOPHENOL is known for its use as a standard in environmental testing and research, particularly in the analysis of polybrominated diphenyl ethers (PBDEs) and their metabolites.
Uses
Used in Environmental Testing and Research:
2,4,5-Tribromophenol is used as a standard for environmental testing and research to determine the presence and concentration of urinary bromophenols (BrPs). These bromophenols serve as potential biomarkers for human exposure to polybrominated diphenyl ethers (PBDEs), which are a group of persistent organic pollutants known for their adverse effects on human health and the environment.
Used in Analytical Chemistry:
In the field of analytical chemistry, 2,4,5-tribromophenol is utilized as a reference compound for the development and validation of analytical methods. One such method involves the use of gas chromatography-tandem mass spectrometry (GC-MS/MS) to accurately measure and identify BrPs in various environmental and biological samples.
Used in Toxicological Studies:
2,4,5-Tribromophenol is also employed in toxicological studies to investigate the inhibitory potency of specific PBDE congeners, such as BDE-47 and BDE-99, on the cytochrome P450 2B6 (CYP2B6)-mediated metabolism of various compounds, including the pharmaceutical drug bupropion. This helps researchers understand the potential interactions between PBDEs and other chemicals in the human body, which can have implications for human health risk assessment.
Check Digit Verification of cas no
The CAS Registry Mumber 14401-61-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,0 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14401-61:
(7*1)+(6*4)+(5*4)+(4*0)+(3*1)+(2*6)+(1*1)=67
67 % 10 = 7
So 14401-61-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Br3O/c7-3-1-5(9)6(10)2-4(3)8/h1-2,10H
14401-61-7Relevant articles and documents
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Henley,Turner
, p. 933 (1930)
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Polybrominated diphenyl ethers (BDEs); preparation of reference standards and fluorinated internal analytical standards
Liu, Huiling,Bernhardsen, Monica,Fiksdahl, Anne
, p. 3564 - 3572 (2007/10/03)
Four new difluorinated tetra- and pentabromo BDE internal standards for GC-MS/GC-ECD analysis, 2F-BDE 47, 2F-BDE 85, 2F-BDE 99 and 2F-BDE 119, have been prepared in 98-99.0% purity, mainly by coupling of the new tribromodifluorophenols (19-21) and symmetr
Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway
Chen,Konstantinov,Chittim,Joyce,Bols,Bunce
, p. 3749 - 3756 (2007/10/03)
Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding assays, and determined their ability to induce hepatic cytochrome P-450 enzymes by means of EROD (ethoxyre-sorufin-O-deethylase) assays in human, rat, chick, and rainbow trout cells. Both pure PBDE congeners and commercial PBDE mixtures had Ah receptor binding affinities 10-2-10-5 times that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In contrast with polychlorinated biphenyls, Ah receptor binding affinities of PBDEs could not be related to the planarity of the molecule, possibly because the large size of the bromine atoms expands the Ah receptor's binding site. EROD activities of the PBDE congeners followed a similar rank order in all cells. Some congeners, notably PBDE 85, did not follow the usual trend in which strength of Ah receptor binding affinity paralleled P-450 induction potency. Use of the gel retardation assay with a synthetic oligonucleotide indicated that in these cases the liganded Ah receptor failed to bind to the DNA recognition sequence.