144242-25-1

Basic information

• Product Name: Silane, trimethyl[3-(triphenylmethoxy)-1-propynyl]-
• CAS NO: 144242-25-1
• Molecular Formula: C25H26OSi
• Molecular Weight: 370.566
• Mol File: 144242-25-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Silane, trimethyl[3-(triphenylmethoxy)-1-propynyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, trimethyl[3-(triphenylmethoxy)-1-propynyl]-(144242-25-1)
• EPA Substance Registry System: Silane, trimethyl[3-(triphenylmethoxy)-1-propynyl]-(144242-25-1)

Safety Data

• Hazardous Substances Data: 144242-25-1(Hazardous Substances Data)

Upstream product

• 5272-36-6 3-trimethylsilyl-2-propyn-1-ol 
• 76-83-5 trityl chloride 
• 75-77-4 chloro-trimethyl-silane 
• 82816-38-4 1-trityloxy-2-propyne 

Downstream Products

• 218598-52-8 Trimethyl-((Z)-1-methyl-3-trityloxy-propenyl)-silane 
• 144242-26-2 (Z)-3-O-(triphenylmethyl)-1-(trimethylsilyl)prop-1-en-3-ol 

Relevant articles and documents

Towards synthesis of calysterols, marine sterols with cyclopropene moiety in the side chain: Synthesis of 26,27-Dinor-23H-isocalysterol

26,27-Dinor-23H-isocalysterol 24 has been synthesized in 19% yield (6 steps) from ethyl 6β-methoxy-3α,5-cyclo-5α-pregnan-21-oate (18). For construction of the side chain, alkylation of lithium salt of ester 18 with 1-bromo-1,2-dimethyl-c-3-iodomethyl-c-2-(trimethylsilyl)cyclopropane 16 was used. It has been shown that reduction of the ester group in position 21 and rearrangement of the 3,5-cyclosteroid system are compatible with the sidechain functionalities. It has been found that methylation of 1,1-dibromo-2-(trimethylsilyl)cyclopropane is accompanied by an rearrangement involving 1,2-migration of the trimethylsilyl group.