218598-52-8

Basic information

• Product Name: Trimethyl-((Z)-1-methyl-3-trityloxy-propenyl)-silane
• CAS NO: 218598-52-8
• Molecular Weight: 386.609
• Mol File: 218598-52-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Trimethyl-((Z)-1-methyl-3-trityloxy-propenyl)-silane(CAS DataBase Reference)
• NIST Chemistry Reference: Trimethyl-((Z)-1-methyl-3-trityloxy-propenyl)-silane(218598-52-8)
• EPA Substance Registry System: Trimethyl-((Z)-1-methyl-3-trityloxy-propenyl)-silane(218598-52-8)

Safety Data

• Hazardous Substances Data: 218598-52-8(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 5272-36-6 3-trimethylsilyl-2-propyn-1-ol 
• 144242-25-1 Trimethyl-(3-trityloxy-prop-1-ynyl)-silane 
• 74-88-4 methyl iodide 

Relevant articles and documents

Towards synthesis of calysterols, marine sterols with cyclopropene moiety in the side chain: Synthesis of 26,27-Dinor-23H-isocalysterol

26,27-Dinor-23H-isocalysterol 24 has been synthesized in 19% yield (6 steps) from ethyl 6β-methoxy-3α,5-cyclo-5α-pregnan-21-oate (18). For construction of the side chain, alkylation of lithium salt of ester 18 with 1-bromo-1,2-dimethyl-c-3-iodomethyl-c-2-(trimethylsilyl)cyclopropane 16 was used. It has been shown that reduction of the ester group in position 21 and rearrangement of the 3,5-cyclosteroid system are compatible with the sidechain functionalities. It has been found that methylation of 1,1-dibromo-2-(trimethylsilyl)cyclopropane is accompanied by an rearrangement involving 1,2-migration of the trimethylsilyl group.