144319-70-0

Basic information

• Product Name: 1-benzyl-4-<2-(N-formylamino)ethyl>piperidine
• Synonyms: 1-benzyl-4-<2-(N-formylamino)ethyl>piperidine
• CAS NO: 144319-70-0
• Molecular Weight: 246.352
• Mol File: 144319-70-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-<2-(N-formylamino)ethyl>piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-<2-(N-formylamino)ethyl>piperidine(144319-70-0)
• EPA Substance Registry System: 1-benzyl-4-<2-(N-formylamino)ethyl>piperidine(144319-70-0)

Safety Data

• Hazardous Substances Data: 144319-70-0(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 86945-25-7 4-(2-aminoethyl)-1-(phenylmethyl)piperidine 

Downstream Products

• 113028-07-2 [2-(1-Benzyl-piperidin-4-yl)-ethyl]-methyl-amine 
• 144319-94-8 3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-3H-quinazolin-4-one 

Relevant articles and documents

Novel [2-(4-piperidinyl)ethyl](thio)ureas: Synthesis and antiacetylcholinesterase activity

A series of 1-ar(o)yl-3-[2-(1-benzyl-4-piperidinyl)ethyl](thio)urea derivatives was synthesized and evaluated for antiacetylcholinesterase activity. Most aroyl(thio)urea derivatives showed potent inhibitory activity in the sub-micromolar range. A comparable potency was obtained with the aryl(thio)urea analogues by replacing the phenyl with a 2-pyridyl group. The substituted guanidine variations proved to be almost inactive whereas the nitroethylene analogues appeared to be quite efficient. These results were interpreted in terms of the preferential cis-trans conformation of the aroyl(thio)urea and 2-pyridyl(thio)urea moieties involving the existence of hydrogen bonding. In vivo experiments showed that compound 7m had maximal antiamnestic activity at 0.03 mg/kg with a therapeutic ratio greater than 1000, while cholinergic side effects were only seen at doses 100-fold the maximally effective antiamnestic dose. Compound 7m represents a potentially interesting antidementia agent.