144539-77-5

Basic information

• Product Name: ((S)-piperidin-3-yl)methanol
• Synonyms: ((S)-piperidin-3-yl)methanol;(3S)-piperidin-3-ylMethanol;(3S)-3-PiperidineMethanol;3(S)-Piperidinemethanol;(S)-3-Hydroxymethyl-piperidine, 99.8%ee, 98%;(S)-Piperidine-3-methanol
• CAS NO: 144539-77-5
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Product Categories: Chiral Reagents;Heterocycles;Intermediates
• Mol File: 144539-77-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 240.4 °C at 760 mmHg
• Flash Point: 92.3 °C
• Appearance: /
• Density: 0.951
• Vapor Pressure: 0.00664mmHg at 25°C
• Refractive Index: 1.451
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.93±0.10(Predicted)
• CAS DataBase Reference: ((S)-piperidin-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-piperidin-3-yl)methanol(144539-77-5)
• EPA Substance Registry System: ((S)-piperidin-3-yl)methanol(144539-77-5)

Safety Data

• Hazardous Substances Data: 144539-77-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 144539-77-5 differently. You can refer to the following data:
1. ((S)-piperidin-3-yl)methanol is used to study enzymic chemoselective and enantioselective acyl transfers in hydroxymethylpiperidines.
2. (S)-3-Piperidinemethanol is used to study enzymic chemoselective and enantioselective acyl transfers in hydroxymethylpiperidines.

InChI:InChI=1/C6H13NO/c8-5-6-2-1-3-7-4-6/h6-8H,1-5H2/t6-/m0/s1

Upstream product

• 37675-18-6 (S)-(+)-nipecotic acid ethyl ester 
• 71962-74-8 Ethyl nipecotate 
• 5621-43-2 diethyl 2-methyleneglutarate 
• 851956-01-9 (S)-(+)-3-piperidinecarboxylic acid hydrochloride 
• 140645-20-1 t-butyl (R,S)-3-<(butyryloxy)methyl>-1-piperidine-carboxylate 
• 175694-36-7 (3R,5S)-Piperidine-1,3,5-tricarboxylic acid 1-benzyl ester 3-methyl ester 
• 88466-73-3 Z-β²hPro-OMe 
• 1221818-73-0 (3S,5R)-Piperidine-1,3,5-tricarboxylic acid benzyl ester dimethyl ester 
• 405061-52-1 N-Cbz-3-hydroxymethylpiperidine 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 

Downstream Products

• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 140645-22-3 (3S)-3-azidomethyl-1-(tert-butoxycarbonyl)-piperidine 
• 140645-23-4 1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate 
• 1325233-13-3 2-amino-N-{((3R)-1-cyclohexylmethyl-3-piperidyl)methyl}acetamide 
• 1382481-80-2 V⁽⁶³⁵⁾U₀₄₉₃ 
• 323183-66-0 ((3S)-1-cyclohexylmethyl-3-piperidyl)methanol 

Relevant articles and documents

Manganese Catalyzed Hydrogenation of Enantiomerically Pure Esters

A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.

PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED 3-HYDROXYMETHYLPIPERIDINE

The present invention relates to a process for preparing enantiomerically enriched 3-hydroxymethylpiperidine and in particular of the S-enantiomer of (S)-3-hydroxymethyl- piperidine in high chemical and optical purity. The invention also relates to extremely pure (S)-3-hydroxymethylpiperidine and (R)-3-hydroxymethylpiperidine.

FUSED BENZENE DERIVATIVE AND USE

The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.