1445856-36-9

Basic information

• Product Name: 6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-4-oxide
• Synonyms: 6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-4-oxide
• CAS NO: 1445856-36-9
• Molecular Weight: 322.772
• Mol File: 1445856-36-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-4-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-4-oxide(1445856-36-9)
• EPA Substance Registry System: 6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-4-oxide(1445856-36-9)

Safety Data

• Hazardous Substances Data: 1445856-36-9(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1021339-19-4 6-chloro-1H-pyrrolo[3,2-b]pyridine 
• 1445856-35-8 6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridine 

Downstream Products

• 1445856-38-1 1-(6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone 
• 1445856-39-2 1-(6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone oxime 
• 1445856-34-7 1-(6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanamine 
• 1445856-73-4 N²-(1-(6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)-N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine 
• 1445856-37-0 6-chloro-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile 

Relevant articles and documents

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

A series of 4-azaindole-containing p21-activated kinase-1 (PAK1) inhibitors was prepared with the goal of improving physicochemical properties relative to an indole starting point. Indole 1 represented an attractive, non-basic scaffold with good PAK1 affinity and cellular potency but was compromised by high lipophilicity (c log D = 4.4). Azaindole 5 was designed as an indole surrogate with the goal of lowering log D and resulted in equipotent PAK1 inhibition with a 2-fold improvement in cellular potency over 1. Structure–activity relationship studies around 5 identified additional 4-azaindole analogs with superior PAK1 biochemical activity (Kia 20-fold decrease in unbound clearance in mouse PK studies for azaindole 5 relative to indole 1.