144690-92-6Relevant articles and documents
Method for preparing high-purity trityl olmesartan medoxomil
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Paragraph 0030-0033, (2019/11/13)
The invention relates to a method for preparing high-purity trityl olmesartan medoxomil. An inorganic salt solution is adopted for cooling and crystallization. The trityl olmesartan medoxomil preparedby the method has high purity. The method avoids use of
A high purity of the preparation process of trityl olmesartan medoxomil
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Paragraph 0020; 0039-0044, (2019/03/21)
The invention discloses a preparation method of a triphenyl methyl olmesartan intermediate compound I. The method comprises the steps of a) hydrolyzing a compound II in the presence of alkali to generate a compound III; b) performing a condensation reaction on the compound III and a compound IV in the presence of a catalyst to prepare a compound I; c) adding water in the step b), and then extracting by using a halogenated hydrocarbon solvent system; d) concentrating the compound I obtained in the step c). The equation is as shown in the specification. The preparation method disclosed by the invention is mild in reaction conditions, small in by-products, high in purity of final products and high in yield; the preparation process is environment-friendly, and is low in wastewater production and beneficial in industrial mass production.
A olmesartan medoxomil and its preparation method (by machine translation)
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, (2017/11/16)
The invention discloses a olmesartan medoxomil and its preparation method, the present invention discloses a olmesartan medoxomil, its chemical structure is: The present invention novel method for preparation method, comprises the following steps: (1) preparing AMST - 3 C45 H44 N6 O3 ; (2) preparing C43 H39 N6 NaO3 AMST - 4; (3) preparing C48 H44 N6 O6 AMST - 6; (4) preparing olmesartan sha tanzhi thick; (5) to make the C29 H30 N6 O6 Olmesartan medoxomil. The invention separation effect is good, relatively low viscosity system, split-phase required time is short, the time is saved but also reduces energy consumption. Filtering and separating the high recovery rate, the product quality is high, the running cost is low; process without the need to add chemical, solvent solvent, not into the secondary pollution material; equipment and automatic operation, good stability, easy to realize industrial demand. (by machine translation)