144985-81-9

Basic information

• Product Name: (1R,2R)-ethyl 1,2-bis(hydroxymethyl)cyclopropanecarboxylate
• Synonyms: (1R,2R)-ethyl 1,2-bis(hydroxymethyl)cyclopropanecarboxylate;ethyl (1R,2R)-1,2-bis(hydroxymethyl)cyclopropane-1-carboxylate
• CAS NO: 144985-81-9
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.19436
• EINECS: -0
• Mol File: 144985-81-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 276.4±5.0 °C(Predicted)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• PKA: 15.10±0.10(Predicted)
• CAS DataBase Reference: (1R,2R)-ethyl 1,2-bis(hydroxymethyl)cyclopropanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-ethyl 1,2-bis(hydroxymethyl)cyclopropanecarboxylate(144985-81-9)
• EPA Substance Registry System: (1R,2R)-ethyl 1,2-bis(hydroxymethyl)cyclopropanecarboxylate(144985-81-9)

Safety Data

• Hazardous Substances Data: 144985-81-9(Hazardous Substances Data)

Usage

General Description

"(1R,2R)-ethyl 1,2-bis(hydroxymethyl)cyclopropanecarboxylate" is a chemical compound with the molecular formula C9H16O4. It is a derivative of cyclopropane carboxylic acid, containing two hydroxymethyl groups attached to the cyclopropane ring. (1R,2R)-ethyl 1,2-bis(hydroxymethyl)cyclopropanecarboxylate is commonly used in organic and medicinal chemistry for the synthesis of various pharmaceuticals and bioactive molecules. Its stereospecificity (1R,2R) indicates the arrangement of substituent groups around the cyclopropane core, which is crucial for its chemical reactivity and pharmacological properties. The ethyl ester functionality allows for ease of handling and manipulation in chemical reactions, making it a versatile building block for the synthesis of complex organic compounds.

Upstream product

• 145032-58-2 ethyl (1S,5R)-2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate 
• 105-53-3 diethyl malonate 

Downstream Products

• 1384867-02-0 ethyl 2-(1-(hydroxymethyl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)cyclopropyl)-acetate 
• 1384867-03-1 ethyl 2-(2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-1-((tosyloxy)methyl)cyclopropyl)-acetate 
• 1384867-04-2 ethyl 2-(1-(fluoromethyl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)cyclopropyl)-acetate 
• 1204820-70-1 ethyl (1R,5R)-3-(phenylmethyl)-3-azabicyclo[3.1.0]hexane-1-carboxylate 
• 1428427-13-7 C₂₄H₃₂O₄Si 
• 1428427-25-1 C₃₈H₄₇NO₄Si 
• 1428427-23-9 C₃₈H₄₃NO₄Si 
• 1428427-21-7 C₃₄H₃₉NO₃Si 
• 1428427-89-7 C₄₀H₄₃F₃N₂O₅ 
• 1428427-90-0 C₄₀H₄₃F₃N₂O₅ 
• 1428427-79-5 C₆₄H₇₃N₇O₆ 
• 1428427-77-3 C₅₃H₅₄N₄O₃ 

Relevant articles and documents

Synthesis of 1,1,2-trisubstituted cyclopropane nucleosides in enantiomerically pure forms

Due to the unique rigid and small steric feature of cyclopropane, cyclopropane nucleosides (CPNs) in which the ribose (deoxyribose) of nucleosides are replaced by a hydroxy-substituted cyclopropane, are of great biological interest. Novel 1,1,2-trisubstit

METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES

The present invention relates to the preparation of cyclopropane derivatives, in particular 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-4,8-dihydro-1H-purin-6-one, especially via the [(1S,7R)-4-phenyl-3,5-dioxabicyclo[5.1.0]octan-1-yl]methanol intermediate.

Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain

Conformationally restricted peptidomimetics comprising eight stereoisomeric scaffolds with three-dimensional structural diversity were designed based on the structural features of cyclopropane, that is, cyclopropylic strain, which mimic wide-ranging tetra