145032-58-2

Basic information

• Product Name: 3-Oxabicyclo[3.1.0]hexane-1-carboxylic acid, 2-oxo-, ethyl ester, (1S,5R)-
• CAS NO: 145032-58-2
• Molecular Formula: C8H10O4
• Molecular Weight: 170.165
• Mol File: 145032-58-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Oxabicyclo[3.1.0]hexane-1-carboxylic acid, 2-oxo-, ethyl ester, (1S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxabicyclo[3.1.0]hexane-1-carboxylic acid, 2-oxo-, ethyl ester, (1S,5R)-(145032-58-2)
• EPA Substance Registry System: 3-Oxabicyclo[3.1.0]hexane-1-carboxylic acid, 2-oxo-, ethyl ester, (1S,5R)-(145032-58-2)

Safety Data

• Hazardous Substances Data: 145032-58-2(Hazardous Substances Data)

Usage

General Description

3-Oxabicyclo[3.1.0]hexane-1-carboxylic acid, 2-oxo, ethyl ester, (1S,5R)- is a chemical compound with the molecular formula C8H12O3. It is an ethyl ester of a bicyclic carboxylic acid and has a stereochemistry of (1S,5R). 3-Oxabicyclo[3.1.0]hexane-1-carboxylic acid, 2-oxo-, ethyl ester, (1S,5R)- is commonly used in organic synthesis and as a building block for the preparation of pharmaceuticals and agrochemicals. Its unique bicyclic structure and carbonyl group make it a versatile intermediate in the synthesis of various organic compounds. Additionally, it has potential applications in the development of new materials and fine chemicals due to its unique structural and stereochemical properties.

Upstream product

• 1440528-09-5 1-allyl 3-ethyl 2-(diphenylsulfuranylidene)malonate 
• 15973-34-9 ethyl 2-propen-1-yl malonate 
• 14208-48-1 ethyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 105-53-3 diethyl malonate 

Downstream Products

• 144985-81-9 ethyl (1R,2R)-1,2-bis(hydroxymethyl)-1-cyclopropanecarboxylate 
• 184838-77-5 (+)-(1R,5S)-ethyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate 
• 950751-45-8 (1aS,2aS)-ethyl 2-formyl 8,8a-dihydro-1aH-cyclopropa[c]pyrrolo[1,2-a]indole-1a-carboxylate 
• 63095-51-2 (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one 
• 357336-20-0 brivaracetam 
• 1428428-15-2 C₆₄H₇₃N₇O₆ 
• 1428428-14-1 C₅₃H₅₄N₄O₃ 
• 1428428-13-0 C₅₈H₆₀N₄O₄ 
• 1428428-12-9 C₃₇H₅₀N₂O₄S 
• 1428427-25-1 C₃₈H₄₇NO₄Si 
• 1428439-38-6 C₆₄H₇₃N₇O₆ 

Relevant articles and documents

Lipase-catalyzed synthesis of a tri-substituted cyclopropyl chiral synthon: A practical method for preparation of chiral 1-alkoxycarbonyl-2-oxo- 3-oxabicyclo[3.1.0]hexane

An efficient method for the preparation of optically active enantiomers of 1-ethoxycarbonyl-2-oxo-3-oxabicyclo[3.1.0]hexane 1 has been developed. Treatment of 1 with lipase Amano PS gave (1S,5R)-1-carboxy-2-oxo-3- oxabicyclo[3.1.0]hexane 4a which was converted to (1S,5R)-1-ethoxycarbonyl-2- oxo-3-oxabicyclo[3.1.0]hexane 1a with high enantiomeric purity (98.0% ee, 75% yield), while the (1R,5S)-lactone ester 1b remained intact. A simple procedure for the recovery of 4a from the reaction mixture was also established.

CsF in organic synthesis. A convenient synthesis of cyclopropanolactone from glycidyl nosylate

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