1450-81-3 Usage
Description
2,5-Dibromovaleric Acid is an organic compound characterized by the presence of two bromine atoms at the 2nd and 5th carbon positions of a pentanoic acid chain. It is a valuable chemical intermediate due to its unique structural features and reactivity, which allows for various synthetic applications in different industries.
Uses
Used in Pharmaceutical Industry:
2,5-Dibromovaleric Acid is used as a chemical intermediate for the synthesis of inhibitors targeting aminoglycoside-resistant bacteria. These inhibitors are crucial in the development of new antibiotics to combat the growing issue of antibiotic resistance.
Used in Biochemical Research:
In the field of biochemical research, 2,5-Dibromovaleric Acid is utilized in the preparation of sequence-specific base pair mimics. These mimics serve as topoisomerase IB inhibitors, playing a significant role in studying and understanding the mechanisms of DNA replication, transcription, and repair. The development of such inhibitors can also contribute to the discovery of novel anticancer and antiviral agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1450-81-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,5 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1450-81:
(6*1)+(5*4)+(4*5)+(3*0)+(2*8)+(1*1)=63
63 % 10 = 3
So 1450-81-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H8Br2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3H2,(H,8,9)
1450-81-3Relevant articles and documents
Isenberg et al.
, p. 831 (1962)
Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
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Page column 11, (2010/02/05)
The invention relates to a process for synthesizing piperazic acid and similar, ring-containing acids. The invention also relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of either or both processes in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1β converting enzyme (“ICE”).
Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions
Okawara, Tadashi,Matsuda, Takashi,Furukawa, Mitsuru
, p. 1225 - 1233 (2007/10/02)
Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation
