1453211-48-7

Basic information

• Product Name: 2,4-dichloro-3-ethynyl-1,5-dimethoxybenzene
• Synonyms: 2,4-dichloro-3-ethynyl-1,5-dimethoxybenzene
• CAS NO: 1453211-48-7
• Molecular Weight: 231.078
• Mol File: 1453211-48-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4-dichloro-3-ethynyl-1,5-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-3-ethynyl-1,5-dimethoxybenzene(1453211-48-7)
• EPA Substance Registry System: 2,4-dichloro-3-ethynyl-1,5-dimethoxybenzene(1453211-48-7)

Safety Data

• Hazardous Substances Data: 1453211-48-7(Hazardous Substances Data)

Usage

General Description

2,4-dichloro-3-ethynyl-1,5-dimethoxybenzene is a chemical compound with a molecular formula C10H8Cl2O2. It is a derivative of benzene with two chlorine atoms, one ethynyl group, and two methoxy groups attached to it. 2,4-dichloro-3-ethynyl-1,5-dimethoxybenzene is used in research and organic synthesis, and its derivatives have been studied for potential pharmacological and therapeutic applications. Its properties and reactivity make it a valuable building block for various organic reactions and the synthesis of more complex molecules. However, it is important to handle this compound with caution as it may be hazardous if not used properly.

Upstream product

• 287175-08-0 2,6-dichloro-3,5-dimethoxy benzaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 171290-52-1 1-Ethynyl-3,5-dimethoxy-benzene 

Downstream Products

• 1453207-56-1 5-[(2,6-dichloro-3,5-dimethoxyphenyl)ethynyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine 

Relevant articles and documents

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Fibroblast growth factor receptor 3 (FGFR3) is an attractive therapeutic target for the treatment of patients with bladder cancer harboring genetic alterations in FGFR3. We identified pyrimidine derivative 20b, which induced tumor regression following ora

NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.