287175-08-0 Usage
Chemical Family
2,6-dichloro-3,5-dimethoxy benzaldehyde belongs to the benzaldehyde family.
Physical State
It is a white solid.
Uses
It is used in the production of pharmaceuticals, fragrances, and as an intermediate in organic synthesis.
Chemical Structure
The compound has two chlorine atoms and two methoxy groups attached to a benzene ring.
Odor and Taste
It has a strong odor and a bitter taste.
Reactivity
It is known for its ability to react with various other chemicals, making it a versatile building block for the creation of new compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 287175-08-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,1,7 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 287175-08:
(8*2)+(7*8)+(6*7)+(5*1)+(4*7)+(3*5)+(2*0)+(1*8)=170
170 % 10 = 0
So 287175-08-0 is a valid CAS Registry Number.
287175-08-0Relevant articles and documents
Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping
Wang, Yikai,Chen, Zhengxia,Dai, Meibi,Sun, Peipei,Wang, Chunqiu,Gao, Yang,Zhao, Haixia,Zeng, Wenqin,Shen, Liang,Mao, Weifeng,Wang, Tian,Hu, Guoping,Li, Jian,Chen, Shuhui,Long, Chaofeng,Chen, Xiaoxin,Liu, Junhua,Zhang, Yang
supporting information, p. 2420 - 2423 (2017/05/10)
Introduction of a Michael acceptor on a flexible scaffold derived from pan-FGFR inhibitors has successfully yielded a novel series of highly potent FGFR4 inhibitors with selectivity over FGFR1. Due to reduced lipophilicity and aromatic ring count, this series demonstrated improved solubility and permeability. However, plasma instability and fast metabolism limited its potential for in vivo studies. Efforts have been made to address these problems, which led to the discovery of compound (?)-11 with improved stability, CYP inhibition, and good activity/selectivity for further optimization.
