145878-50-8Relevant articles and documents
N-Arylation of Carbamates through Photosensitized Nickel Catalysis
Reddy, Leleti Rajender,Kotturi, Sharadsrikar,Waman, Yogesh,Ravinder Reddy, Vudem,Patel, Chirag,Kobarne, Ajinath,Kuttappan, Sasikumar
, p. 13854 - 13860 (2018/10/31)
A highly efficient method of visible light mediated Ni(II)-catalyzed photoredox N-arylation of Cbz-amines/Boc-amines with aryl electrophiles at room temperature is reported. The methodology provides a common access to a wide variety of N-aromatic and N-heteroaromatic carbamate products that find use in the synthesis of several biologically active molecules and provides a distinct advantage over traditional palladium-catalyzed Buchwald reaction.
Palladium(II)-catalyzed direct conversion of methyl arenes into aromatic nitriles
Shu, Zhibin,Ye, Yuxuan,Deng, Yifan,Zhang, Yan,Wang, Jianbo
supporting information, p. 10573 - 10576 (2013/10/21)
From methyl to nitrile: A mild ammoxidation method, which directly converts methyl arenes into aromatic nitriles, has been developed by using Pd(OAc) 2 and N-hydroxyphthalimide (NHPI) as the catalysts, and tert-butyl nitrite as the nitrogen source and oxidant. Copyright
Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1′ and P4 positions
Tagad, Harichandra D.,Hamada, Yoshio,Nguyen, Jeffrey-Tri,Hamada, Takashi,Abdel-Rahman, Hamdy,Yamani, Abdellah,Nagamine, Ayaka,Ikari, Hayato,Igawa, Naoto,Hidaka, Koushi,Sohma, Youhei,Kimura, Tooru,Kiso, Yoshiaki
experimental part, p. 3175 - 3186 (2010/07/04)
We previously reported potent BACE1 inhibitors KMI-420 and KMI-570 possessing a hydroxymethylcarbonyl isostere as a substrate transition-state mimic. Acidic moieties at the P1′ and P4 positions of KMI inhibitors are thought to be unfavorable in terms of membrane permeability across the blood-brain barrier. Herein, we replaced acidic moieties at the P4 position with hydrogen bond accepting groups and acidic moieties at the P1′ position with less acidic and similar molecular-size moieties (carboxylic acid or tetrazole bioisosteres). These inhibitors exhibited improved BACE1 inhibitory activities and a thorough quantitative structure-activity relationship study was performed.