146137-74-8

Basic information

• Product Name: 2-Fluoro-6-methoxybenzaldehyde
• Synonyms: RARECHEM AK VD 0022;6-FLUORO-O-ANISALDEHYDE;2-FLUORO-6-METHOXYBENZALDEHYDE;2-METHOXY-6-FLUOROBENZALDEHYDE;Benzaldehyde, 2-fluoro-6-methoxy- (9CI);2-Fluoro-6-mehoxybenzaldehyde;2-Fluoro-6-methoxybenzaldehyde 99%;2-Fluoro-6-methoxybenzaldehyde99%
• CAS NO: 146137-74-8
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• EINECS: 1312995-182-4
• Product Categories: HALIDE;ALDEHYDE;Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 146137-74-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 59-63 °C(lit.)
• Boiling Point: 218.5 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: White to tan/5 wt.% in methanol
• Density: 0.807 g/mL at 25 °C
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: n20/D 1.339
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Fluoro-6-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-6-methoxybenzaldehyde(146137-74-8)
• EPA Substance Registry System: 2-Fluoro-6-methoxybenzaldehyde(146137-74-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 1230 3/PG 2
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 146137-74-8(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystalline

InChI:InChI=1/C7H4FIO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H

Upstream product

• 456-49-5 1-fluoro-3-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 94088-46-7 2-fluoro-6-methoxybenzonitrile 
• 50-00-0 formaldehyd 
• 372-20-3 3-fluorophenol 
• 77-78-1 dimethyl sulfate 
• 137654-21-8 2-fluoro-6-methoxybenzoic acid 
• 253668-46-1 2-fluoro-6-methoxybenzyl alcohol 
• 2591-86-8 N-Formylpiperidine 
• 3030-47-5 N,N,N',N'',N'''-pentamethyldiethylenetriamine 

Downstream Products

• 171179-83-2 2-fluoro-6-methoxybenzaldoxime 
• 934986-87-5 1-(4-fluorophenyl)-4-methoxy-1H-indazole 
• 1357928-12-1 C₁₇H₁₆O₅ 
• 1357928-07-4 6-methoxy-2-(p-tolyloxy)benzaldehyde 
• 1357928-09-6 2-(2,6-dimethyl)phenoxy-6-methoxybenzaldehyde 
• 1357928-11-0 2-(p-methoxy)phenoxy-6-methoxybenzaldehyde 
• 1357927-88-8 2-(3,5-dimethyl)phenoxy-6-methoxybenzaldoxime 
• 1357927-94-6 2-(3,5-dimethyl)phenoxy-6-methoxybenzonitrile N-oxide 
• 1357927-89-9 2-(2,6-dimethyl)phenoxy-6-methoxybenzaldoxime 
• 1357927-95-7 2-(2,6-dimethyl)phenoxy-6-methoxybenzonitrile N-oxide 
• 1357927-90-2 2-phenoxy-6-methoxybenzaldoxime 
• 1357927-96-8 2-phenoxy-6-methoxybenzonitrile N-oxide 
• 1357927-91-3 2-(p-methoxy)phenoxy-6-methoxybenzaldoxime 
• 1357927-97-9 2-(p-methoxy)phenoxy-6-methoxybenzonitrile N-oxide 

Relevant articles and documents

List fluoro Radicamine compounds and their use and preparation method

The invention discloses a mono-fluorinated Radicamine compound which has a structure as shown in a formula (1), and further provides a preparation method for the mono-fluorinated Radicamine compound with the structure as shown in the formula (1) and an application of the mono-fluorinated Radicamine compound or the mono-fluorinated Radicamine compound prepared with the method to preparation of drugs for preventing and/or treating diabetes, drugs for preventing and/or treating Gaucher's diseases, drugs for preventing and/or treating tumors or antiviral drugs. The mono-fluorinated Radicamine compound provided by the invention is good in glycosidase inhibition activity.

Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition

Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. Fluorinated derivatives of radicamine A and B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies revealed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom.

MULTIPLE KINASE PATHWAY INHIBITORS

Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.