14726-36-4Relevant articles and documents
Synthesis, crystal structure and in vitro anticancer studies of bis(dibenzyldithiocarbamato)Zn(II)
Ajibade, Peter A.,Sikakane, Berlinda M.,Oluwalana, Abimbola E.,Paca, Athandwe M.,Singh, Moganavelli
, p. 1244 - 1254 (2021)
Bis(dibenzyldithiocarbamato)Zn(II), [Zn(dbzdtc)2], was synthesized and characterized by spectroscopic techniques, elemental analysis and single crystal X-ray crystallography. The compound is crystallized in a monoclinic space group P21/n with Zn(II) located on crystallographic twofold symmetry and coordinated to two molecules of dibenzyl dithiocarbamato anions to form a rare four-coordinate mononuclear Zn(II) complex in a see-saw geometry. The cytotoxicity of the complex was evaluated by MTT assay against breast cancer cells (MCF-7) and human embryonic kidney cells (HEK293). The results showed that the complex is active against MCF-7 breast cancer cells with IC50 value of 6.41 and 4.423?μΜ against HEK293 cell line.
Method for preparing crystal form thioamino carboxylate by taking secondary amine as raw material
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Paragraph 0053-0056, (2020/05/01)
The invention relates to a method for preparing crystal form thioamino carboxylate by taking secondary amine as a raw material, namely a method for preparing the crystal form thioamino carboxylate bya one-step method through a mixed reaction of the secondary amine, carbon disulfide, metal oxide or hydroxide in water. According to the scheme, conventional reaction equipment and simplified raw materials are used for preparing a high-purity product; the method is low in water consumption, inorganic salt byproducts are not generated, and the reaction mother liquor can be recycled directly or through simple treatment.
Synthesis, spectral, thermal and BVS investigations on ZnS4N^N/N coordination environment: Single crystal X-ray structures of bis(dibenzyldithiocarbamato)(N^N)Zinc(II) complexes (N^N = 1,10-phenanthroline, tetramethylethylenediamine and 4,4′-bipyridine)
Marimuthu,Ramalingam,Rizzoli
, p. 1555 - 1560 (2010/06/20)
The current paper describes the synthesis and spectral investigations on the adducts of [Zn(dbzdtc)2] (1) with 1,10-phen (2), tmed (3), 2,2′-bipy (4) and 4,4′-bipy (5) (where, dbzdtc = dibenzyldithiocarbamate anion, 1,10-phen = 1,10-phenanthroline, tmed = tetramethylethylenediamine, 2,2′-bipy = 2,2′-bipyridine, 4,4′-bipy = 4,4′-bipyridne) and single crystal X-ray structures of [Zn(dbzdtc)2(1,10-phen)] (2) and [Zn(dbzdtc)2(tmed)] (3) and [Zn(dbzdtc)2(4,4′-bipy)] (5). 1H and 13C NMR spectra of 1,10-phen, tmed, 2,2′-bipy and 4,4′-bipy adducts were recorded. 1H NMR spectra of the complexes show the drift of electrons from the nitrogen of the substituents forcing a high electron density towards sulfur via the thioureide π-system. In the 13C NMR spectra, the most important thioureide (N13CS2) carbon signals are observed in the region: 206-210 ppm. Fluorescence spectra of complexes (2) and (4) show intense fluorescence due to the presence of rigid conjugate systems such as 1,10-phenanthroline and 2,2′-bipyridine. The observed fluorescence maxima for complexes with an MS4N2 chromophore in the visible region are assigned to the metal-to-ligand charge transfer (MLCT) processes. Single crystal X-ray structural analysis of (2) and (3) showed that the zinc atom is in a distorted octahedral environment. Bond Valence Sum was found to be equivalent to 1.865 for (2), 1.681 for (3) supporting the correctness of the determined structure. BVS of (3) deviates from the formal oxidation number of zinc due to the non-aromatic, sterically hindering tetramethyl bonding end of tmed. Thermal studies on the compounds show the formation of Zn(NCS)2 as an intermediate during the decay.
