147344-86-3Relevant articles and documents
Gold(I) iodide catalyzed sonogashira reactions
Li, Pinhua,Wang, Lei,Wang, Min,You, Feng
, p. 5946 - 5951 (2008)
Gold(I) iodide catalyzed Sonogashira reactions have been developed. Terminal alkynes reacted with aryl iodides and bromides smoothly in the presence of AuI (1 mol-%) and dppf (1 mol-%) in toluene to generate the corresponding cross-coupling products in good to excellent yields. Furthermore, aromatic terminal alkynes could also react with 2-iodoaniline to form substituted indoles in excellent yields through a coupling-cyclization reaction sequence under the present reaction conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.
Catalytic efficiency of a new tridentate ferrocenyl phosphine auxiliary: Sonogashira cross-coupling reactions of alkynes with aryl bromides and chlorides at low catalyst loadings of 10-1 to 10-4 Mol %
Hierso, Jean-Cyrille,Fihri, Aziz,Amardeil, Regine,Meunier, Philippe,Doucet, Henri,Santelli, Maurice,Ivanov, Vladimir V.
, p. 3473 - 3476 (2004)
(Chemical Equation Presented) The catalytic activity in Sonogashira cross-coupling reactions of alkynes with a variety of aryl halides (including chlorides) using a multidentate ferrocenyl phosphine is presented. The novel mixed ferrocenyl aryl/alkyl trip
Decarbonylative Sonogashira Cross-Coupling of Carboxylic Acids
Liu, Chengwei,Szostak, Michal
supporting information, p. 4726 - 4730 (2021/06/28)
Decarbonylative Sonogashira cross-coupling of carboxylic acids by palladium catalysis is presented. The carboxylic acid is activated in situ by the formation of a mixed anhydride and further decarbonylates using the Pd(OAc)2/Xantphos system to provide an aryl-Pd intermediate, which is intercepted by alkynes to access the traditional Pd(0)/(II) cycle using carboxylic acids as ubiquitous and orthogonal electrophilic cross-coupling partners. The methodology efficiently constructs new C(sp2)-C(sp) bonds and can be applied to the derivatization of pharmaceuticals. Mechanistic studies give support to decarbonylation preceding transmetalation in this process.
A palladium catalyzed aryl alkyne preparation method
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Paragraph 0037; 0038; 0039, (2019/05/21)
The invention discloses a palladium catalyzed aryl alkyne of the preparation method, comprises the following steps: in the catalyst, under the action of the ligand and alkali, substituted with aryl sulfonyl chloride alkynoic occurs in the organic solvent escapes suosuo the coupling reaction, after the reaction is finished after treatment to obtain the aryl alkyne. Used in the preparation method of the cheap raw material, the reaction and simple post treatment operation, at the same time, the reaction less side reaction, high yield of the product.
A phosphine-free, atom-efficient cross-coupling of aryl iodides with triarylindiums or trialkynylindiums catalyzed by immobilization of palladium(0) in MCM-41
Lei, Zhiwei,Liu, Haiyi,Cai, Mingzhong
, p. 54 - 63 (2017/10/25)
The first phosphine-free heterogeneous atom-efficient cross-coupling reaction of aryl iodides with triarylindiums or trialkynylindiums was achieved in THF at 68 °C by using 1 mol% of MCM-41-immobilized palladium(0)-Schiff base complex [MCM-41-N,N-Pd(0)] as catalyst, yielding a variety of unsymmetrical biaryls and arylalkynes in good to excellent yields. The heterogeneous palladium(0) catalyst could easily be prepared via a simple procedure from commercially readily available reagents, and recovered by filtration of the reaction solution and recycled at least 10 times without significant loss of activity.
