147595-55-9

Basic information

• Product Name: 2-Oxazolidinone, 3-(bromoacetyl)-4-methyl-5-phenyl-, (4R,5S)-
• CAS NO: 147595-55-9
• Molecular Formula: C12H12BrNO3
• Molecular Weight: 298.136
• Mol File: 147595-55-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-(bromoacetyl)-4-methyl-5-phenyl-, (4R,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-(bromoacetyl)-4-methyl-5-phenyl-, (4R,5S)-(147595-55-9)
• EPA Substance Registry System: 2-Oxazolidinone, 3-(bromoacetyl)-4-methyl-5-phenyl-, (4R,5S)-(147595-55-9)

Safety Data

• Hazardous Substances Data: 147595-55-9(Hazardous Substances Data)

Upstream product

• 497-25-6 dimethylenecyclourethane 
• 598-21-0 2-Bromoacetyl bromide 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 22118-09-8 2-bromoacetyl chloride 

Downstream Products

• 288385-05-7 [4R-[3(R*),4α,5α]]-3-[4,4-dimethyl-1,5-dioxo-3-hydroxyheptyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 147725-28-8 (4R,5S)-3-<1-oxo-3-(1,3-dithian-2-ylidene)-2-<3,4-(methylenedioxy)benzyl>propyl>-4-methyl-5-phenyl-2-oxazolidinone 
• 147725-24-4 (4R,5S)-3-<1-oxo-3-(1,3-dithian-2-ylidene)-2-benzylpropyl>-4-methyl-5-phenyl-2-oxazolidinone 
• 147725-32-4 (4R,5S)-3-<1-oxo-3-(1,3-dithian-2-ylidene)-2-(2-propyl)propyl>-4-methyl-5-phenyl-2-oxazolidinone 
• 147725-30-2 (4R,5S)-3-<1-oxo-3-(1,3-dithian-2-ylidene)-2-propylpropyl>-4-methyl-5-phenyl-2-oxazolidinone 
• 177977-02-5 C₃₆H₄₅NO₅S₂ 
• 177976-99-7 (4R,5S)-3-((E)-5-{2-[(2E,4E)-9-(4-Methoxy-benzyloxy)-nona-2,4-dienyl]-[1,3]dithian-2-yl}-pent-2-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 177977-03-6 (4R,5S)-3-{(1R,2R,4aS,8aR)-2-[4-(4-Methoxy-benzyloxy)-butyl]-6-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl}-4-methyl-5-phenyl-oxazolidin-2-one 
• 227602-22-4 (4R,5S)-N-<5,5-(trimethylenedithio)-2(E),7(E),9-decatrienoyl>-4-methyl-5-phenyloxazolidin-2-one 
• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 345653-67-0 3-(11'(S)-(tert-Butyldiphenylsilyloxy)-3'S-hydroxy-6'E-dodecenoyl)-4R-methyl-5S-phenyl-2-oxazolidinone 
• 345653-68-1 3-(11'(S)-(tert-Butyldiphenylsilyloxy)-3'R-hydroxy-6'E-dodecenoyl)-4R-methyl-5S-phenyl-2-oxazolidinone 
• 147725-15-3 diethyl 2-<(4R,5S)-4-methyl-2-oxo-5-phenyl-3-oxazolidinyl>-2-oxoethanephosphonate 
• 142722-85-8 (4R,5S)-3-((2S,3R)-2-Bromo-3-hydroxy-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 

Relevant articles and documents

DERMAL COMPOSITIONS CONTAINING UNNATURAL HYGROSCOPIC AMINO ACIDS

Unnatural, hygroscopic amino acids are useful to enhance the moisture retention and uptake properties of skin. In particular, such amino acids are N-hydroxyserine, N- hydroxyglycine, L-homoserine,alpha-hydroxyglycine, 2-(aminooxy) -2-hydroxyacetic acid, 2-hydroxy-2-(hydroxyamino) acetic acid, 2- (aininooxy)acetic acid, and combinations thereof.

EPOTHILONE DERIVATIVES, METHOD FOR PRODUCING SAME AND THEIR PHARMACEUTICAL USE

This invention relates to the new epothilone derivatives of general formula I, 1in which substituents Y, Z R2a, R2b, R3, R4a, R4b, D—E, R5, R6, R7, R8 and X have the meanings that are indicated in more detail in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanomas, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (psoriasis, arthritis). To avoid uncontrolled proliferation of cells and for better compatibility of medical implants, they can be applied or introduced into polymer materials. The compounds according to the invention can be used alone or to achieve additive or synergistic actions in combination with other principles and classes of substances that can be used in tumor therapy.

Studies on a total synthesis of plakotenin: Synthesis of optically active trans-hydrindanes by diastereoselective asymmetric intramolecular diels-alder reaction

Diastereoselective asymmetric intramolecular Diels-Alder reaction of 5,5-(trimethylenedithio)-2(E),7(E),9-decatrienoyl amides (13a-e) having various chiral auxiliaries was performed to give optically active trans- hydrindanes, which would be an important