1481-27-2 Usage
Chemical Properties
Colorless to yellow liquid
Uses
4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.
Preparation
Preparation by Fries rearrangement of 3-fluorophenyl acetate with aluminium chloride without solvent at 160–180° (75%) (88–90%).
General Description
4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P21/n.
Check Digit Verification of cas no
The CAS Registry Mumber 1481-27-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,8 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1481-27:
(6*1)+(5*4)+(4*8)+(3*1)+(2*2)+(1*7)=72
72 % 10 = 2
So 1481-27-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H7FO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2
1481-27-2Relevant articles and documents
A practical synthesis of 2'-fluoro-4'-hydroxyacetophenone
Zhang, Xiao-Bo,Lu, Qun,Xu, Wei-Ming
, p. 419 - 421 (2009)
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SALTS AND SOLID FORMS AND PROCESSES OF PREPARING A PI3K INHIBITOR
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Page/Page column 67; 68, (2021/08/13)
The present disclosure provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), a
HETEROCYCLIC FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO
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Page/Page column 30, (2020/03/02)
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of
