701-83-7Relevant articles and documents
Optimized TrkB Agonist Ameliorates Alzheimer's Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase
Chen, Chun,Ahn, Eun H.,Liu, Xia,Wang, Zhi-Hao,Luo, Shilin,Liao, Jianming,Ye, Keqiang
, p. 2448 - 2461 (2021/06/30)
BDNF/TrkB neurotropic pathway, essential for neural synaptic plasticity and survival, is deficient in neurodegenerative diseases including Alzheimer's disease (AD). Our previous works support that BDNF diminishes AD pathologies by inhibiting delta-secreta
HETEROCYCLIC FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO
-
Page/Page column 29-30, (2020/03/02)
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of
5-6-5 azatricyclic compound and preparation method thereof
-
Paragraph 0033-0036, (2019/10/01)
The embodiment of the invention discloses a preparation method of a 5-6-5 azatricyclic compound. By using 3-fluorophenol as a raw material and through multistep cascade reactions including esterification, rearrangement, oximation, intramolecular cyclizati