148715-93-9

Basic information

• Product Name: N-(diphenylphosphinoyl)glycylglycylphenylalanylmethionine methyl ester
• Synonyms: N-(diphenylphosphinoyl)glycylglycylphenylalanylmethionine methyl ester
• CAS NO: 148715-93-9
• Molecular Weight: 624.698
• Mol File: 148715-93-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(diphenylphosphinoyl)glycylglycylphenylalanylmethionine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(diphenylphosphinoyl)glycylglycylphenylalanylmethionine methyl ester(148715-93-9)
• EPA Substance Registry System: N-(diphenylphosphinoyl)glycylglycylphenylalanylmethionine methyl ester(148715-93-9)

Safety Data

• Hazardous Substances Data: 148715-93-9(Hazardous Substances Data)

Upstream product

• 148715-92-8 N-(diphenylphosphinoyl)glycylphenylalanylmethionine methyl ester 
• 148715-91-7 N-(diphenylphosphinoyl)phenylalanylmethionine methyl ester 
• 2491-18-1 (S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride 
• 62056-86-4 N-(diphenylphosphinoyl)glycine 
• 78553-40-9 glycylphenylalanylmethionine methyl ester hydrochloride 
• 62056-93-3 N_α-diphenylphosphinoylphenylalanine 
• 22248-60-8 L-phenylalanyl-L-methionine methyl ester 

Downstream Products

• 148715-94-0 N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine methyl ester 
• 148715-90-6 N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine 
• 58569-55-4 met-enkephalin 
• 70035-46-0 hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine 

Relevant articles and documents

Phosphorus-based Reagents in Peptide Synthesis: Synthesis of Methionine-Enkephalin and the Solution Conformation of its N-Diphenylphosphinoyl Derivative

Met5enkephalin 1 was synthesized by solution phase synthesis using the diphenylphosphinoyl (Dpp) group for α-amino group protection and diphenylphosphinoyl-carboxylic acid mixed anhydrides for carboxylate activation.These reagents proved to be compatible with both tyrosine and methionine side chain functionalities.A (1)H NMR study of the solution conformation of the N-terminal-protected pentapeptide DppMe5enkephalin 2 in dimethyl sulfoxide suggests that the peptide backbone of this derivative adopts a major conformation possessing a type I' β-bend between residues Gly2-Gyl3 with the side chains of the Tyr1 and Phe4 lying on the same side of the plane of the bend.The predominant conformation of the Phe4 and Met5 side chains appear to be tg+.