15062-72-3

Basic information

• Product Name: N-Demethylbenzphetamine
• Synonyms: N-Demethylbenzphetamine
• CAS NO: 15062-72-3
• Molecular Weight: 225.334
• Mol File: 15062-72-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-Demethylbenzphetamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Demethylbenzphetamine(15062-72-3)
• EPA Substance Registry System: N-Demethylbenzphetamine(15062-72-3)

Safety Data

• Hazardous Substances Data: 15062-72-3(Hazardous Substances Data)

Upstream product

• 673-32-5 1-Phenylprop-1-yne 
• 100-39-0 benzyl bromide 
• 622-79-7 benzyl azide 
• 536-74-3 phenylacetylene 
• 1234572-14-5 (R)-1,2-dibenzylaziridine 
• 77184-95-3 (R)-2-benzylaziridine 
• 13906-90-6 2-benzylaziridine 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 673-06-3 D-(R)-phenylalanine 
• 156-08-1 benzphetamine 
• 103-79-7 1-phenyl-acetone 
• 100-46-9 benzylamine 
• 103-82-2 phenylacetic acid 
• 1085-42-3 1-phenyl-2-benzylaminopropane 

Downstream Products

• 1026631-37-7 C₃₈H₃₉NO₃ 
• 1025958-44-4 C₃₈H₃₉NO₃ 

Relevant articles and documents

Hair analysis for drugs of abuse. XI. Disposition of benzphetamine and its metabolites into hair and comparison of benzphetamine use and methamphetamine use by hair analysis

In order to study the disposition of benzphetamine (BZP) and its metabolites, desmethyl benzphetamine (norBZP), p-hydroxy desmethyl benzphetamine (OHnorBZP), methamphetamine (MA) and amphetamine (AP), from plasma to hair in rats, an analytical method for identifying these drugs in plasma, urine and hair was developed with selected ion monitoring of gas chromatograph/mass spectrometry (GC/MS-SIM) results. After the intraperitoneal administration of BZP to rats (10 mg/kg/d, 10 d, n=3), concentrations of BZP and its metabolites in rat hair newly grown for 4 weeks were compared to the areas under the concentration versus time curve (AUCs) of these drugs in the rat plasma. The concentrations of BZP, norBZP, OHnorBZP, MA and AP in the rat hair were 14.8±1.4, 6.1±0.3, 2.6±0.5, 2.3±0.1 and 9.2±0.3 ng/mg, and the ratio of the concentrations in the hair to AUCs in the rat plasma was 3.0:0.1:0.1:0.6:0.2, respectively. This fact suggested that BZP tends to be readily incorporated into hair from blood. The method was applied to the determination of the metabolites in scalp hair and pubic hair of humans who orally ingested BZP (30 mg/d, 5 d, n=2). BZP, norBZP, MA and AP were detected at 0.14-0.56, 0.29-0.63, 0.10 and 1.06-1.66 ng/mg in the scalp hair and at 0.10-0.20, 0.13-0.18, trace-0.15 and 0.23 ng/mg in the pubic hair, respectively. It was shown that BZP use could be retrospectively distinguished from MA use by the detection of BZP and/or norBZP in hair.

Benzphetamine hydrochloride preparation method

The invention relates to the field of chemical pharmacy, particularly to a benzphetamine hydrochloride preparation method. According to the invention, the method avoids the use of ephedrine, pseudoephedrine, deoxyephedrine and other management and control products, has characteristics of inexpensive and easily-available raw materials and synthesis cost reducing, can obtain the high-purity target compound at high yield, and is suitable for industrial large-scale production.

Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas

This disclosure concerns the discovery of the use of fenoterol and (R,R)- and (R,S)-fenoterol analogs for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2-adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analog or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.