151-83-7

Basic information

• Product Name: Methohexital
• Synonyms: METHOHEXITAL;2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-;2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, (±2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, (.+/-.)-;5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;Barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-;Barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, (±Barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, (.+/-.)-
• CAS NO: 151-83-7
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.3
• EINECS: 205-798-6
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 151-83-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 96 °C(Solv: ethanol (64-17-5))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.113
• Refractive Index: 1.504
• Storage Temp.: 2-8°C
• PKA: 7.82±0.10(Predicted)
• CAS DataBase Reference: Methohexital(CAS DataBase Reference)
• NIST Chemistry Reference: Methohexital(151-83-7)
• EPA Substance Registry System: Methohexital(151-83-7)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 151-83-7(Hazardous Substances Data)

Usage

Description

Methohexital is a short-acting barbiturate, characterized by its structure as barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups. It is classified as a Controlled Substance due to its potent sedative and anesthetic properties.

Uses

Used in Medical Applications:
Methohexital is used as a sedative for various medical procedures, providing patients with a calm and relaxed state during treatment.
Methohexital is used as an anesthetic for:
1. Oral Surgery and Dentistry: It is utilized to induce a state of temporary insensibility to pain, allowing for comfortable and efficient dental or oral surgical procedures.
2. Electroconvulsive Therapy (ECT): Methohexital is used to induce anesthesia prior to ECT, ensuring patient comfort and facilitating the procedure's effectiveness.

InChI:InChI=1/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19)

Downstream Products

• 18652-93-2 (S)-methohexital 
• 18652-93-2 (R)-methohexital 

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The purpose of this study is to evaluate the efficacy and reliability of pharmacologic provocative testing with methohexital (PPTM) using intraoperative neurophysiologic monitoring (IONM) in endovascular embolization procedures (EEPs).111 EEPs cases were retrospectively reviewed between 2014 and...detailed

Supported in part (Dr. Chuang and Dr. Ruiz) by a National Eye Institute (NEI) Vision Core Grant, Bethesda, Maryland.Alfentanil decreases the excitatory phenomena of sodium Methohexital (cas 151-83-7) - effect of rate of injection on incidence of side effects with thiopental and Methohexital (cas 151-83-7)09/28/2019

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