Detail of "151-83-7"

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Self-administration of orally-delivered methohexital in rhesus monkeys with phencyclidine or pentobarbital histories: Effects of food deprivation and satiation

Self-administration of orally-delivered methohexital in rhesus monkeys with phencyclidine or pentobarbital histories: Effects of food deprivation and satiation. Carroll, Marilyn E.; Stotz, Dana C.; Kliner, Dale J.Several substances are used for example 76-74-4 and 77-10-1 which are their cas registry numbers.; Meisch, Richard A. (Psychiatry Dep., Univ. Minnesota, Minneapolis, MN 55455, USA). Pharmacol., Biochem. Behav., 20(1), 145-51 (English) 1984. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Orally-delivered methohexital [151-83-7] was demonstrated to function as a reinforcer for rhesus monkeys with either phencyclidine [77-10-1] or pentobarbital [76-74-4] self-administration histories. The effects of food deprivation and food satiation were compared across a wide range of methohexital concns. Initially, 3 monkeys were trained to orally self-administer phencyclidine (0.25 mg/mL) and water, and three were trained to orally self-administer pentobarbital (0.5 mg/mL) and water under concurrent fixed-ratio (FR) schedules during daily 3-h sessions. The monkeys were first tested while food deprived by maintaining them at 85% of their free-feeding body wts. Methohexital concns. were presented in the following order, and each concn. was held const. until at least 5 or 6 sessions of stable behavior were obtained: 2, 2.8, 4, 2 (retest), 1, 0.5, (plus 0.25 and 0.125 in monkey M-W) and 2 (retest) mg/mL. The monkeys were then food satiated by allowing them unlimited access to food, and the methohexital concn. series was repeated. During food deprivation, the concn.-response functions generally resembled an inverted U. Concurrent water-maintained responding was generally low, but it increased in some monkeys as methohexital concns. increased in some monkeys. During food satiation, methohexital-maintained responding was not different from water-maintained responding in some monkeys, but in others it was substantially higher than water-maintained responding. Max. drug intake ranged from 20.4 to 93.8 mg/kg during food deprivation and from 6.4 to 64.2 during food satiation among the 6 monkeys. During food deprivation, most methohexital-maintained responding occurred during the first half of the 3-h session; however, during food satiation, responding was evenly distributed throughout the 3-h session. The time course of water-maintained responding was not altered as a result of changes in the feeding condition. Generally it appeared that methohexital was more easily substituted for pentobarbital than it was for phencyclidine, and higher rates of performance were maintained in the pentobarbital-trained monkeys. .

The interaction between atropine and some lipid-soluble barbiturates in rats

The interaction between atropine and some lipid-soluble barbiturates in rats. Bolander, Hans G.; Wahlstroem, Goeran (Dep. Pharmacol., Univ. Umeaa, Umea S-90187, Swed.). Acta Pharmacol. Toxicol., 54(2), 81-5 (English) 1984. CODEN: APTOA6. ISSN: 0001-6683. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of atropine [51-55-8] pretreatment on the CNS (central nervous system) sensitivity to 5 lipid-sol. barbiturates was studied in rats. Atropine in a dose of 8 mg/kg i.p. or saline was given 1.5 h before an EEG-threshold detn. with the tested barbiturates. The barbiturate was infused by const. rate through a tail vein. The dose of barbiturate needed to induce a burst suppression period in the EEG 1 s or longer was used as the threshold dose. 56-29-1 and 67-52-7 which are cas registry numbers of substances are two of reagents here. Atropine pretreatment decreased the threshold dose significantly for 2 N-methylated barbiturates, hexobarbital [56-29-1] and methohexital [151-83-7] but not for thiopental [76-75-5], pentobarbital [76-74-4] or amobarbital [57-43-2]. No clear effects of atropine pretreatment could be found in the ensuing anesthesia times after threshold detns. These results indicate that there are differences in mechanisms of action between barbiturates. One of these mechanisms is related to the cholinergic system in the CNS. .