1517-63-1

Basic information

• Product Name: 4-Methylbenzhydrol
• Synonyms: 4-Methylbenzhyldrol;4-Methyldiphenylmethanol~Phenyl p-tolyl carbinol;alpha-p-tolylbenzyl alcohol;4-Methylbenzhydrol, 98+%;PHENYL-4-METHYLPHENYLMETHANOL;p-Methylbenzhydrol;Benzenemethanol, 4-methyl-alpha-phenyl-;4-Methylbenzhydryl alcohol
• CAS NO: 1517-63-1
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.26
• EINECS: 216-171-1
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 1517-63-1.mol
• Article Data: 258

Chemical Properties

• Melting Point: 50-54 °C(lit.)
• Boiling Point: 295.58°C (rough estimate)
• Flash Point: >230 °F
• Appearance: white to off-white powder
• Density: 1.0074 (rough estimate)
• Vapor Pressure: 4.89E-05mmHg at 25°C
• Refractive Index: 1.5381 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.68±0.20(Predicted)
• BRN: 2048849
• CAS DataBase Reference: 4-Methylbenzhydrol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylbenzhydrol(1517-63-1)
• EPA Substance Registry System: 4-Methylbenzhydrol(1517-63-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 1517-63-1(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white powder

Uses

4-Methyl-α-phenylbenzenemethanol is used in the synthesis of tropane analogs in the inhibition of binding at the dopamine transporter. Also is used in SAR studies relating to diphenylpiperazine N-type calcium channel inhibitors, analyzing their anti-hyperalgesic activity.

InChI:InChI=1/C14H14O/c1-11-7-9-13(10-8-11)14(15)12-5-3-2-4-6-12/h2-10,14-15H,1H3/t14-/m1/s1

Upstream product

• 834-25-3 4-methylphenyl benzyl ether 
• 56-23-5 tetrachloromethane 
• 14338-21-7 tri-(4-methylphenyl)aluminum 
• 100-52-7 benzaldehyde 
• 6749-78-6 4-methylphenylmagnesium iodide 
• 109-72-8 n-butyllithium 
• 134-84-9 4-Methylbenzophenone 
• 18412-57-2 p-tolyltriethoxysilane 
• 75-89-8 2,2,2-trifluoroethanol 
• 116664-91-6 4-(Phenyl-p-tolyl-methoxy)-benzonitrile 
• 960-71-4 triphenylborane 
• 106-43-4 para-chlorotoluene 
• 23418-91-9 9-phenyl-9-borabicyclo[3.3.1]nonane 
• 100-59-4 phenylmagnesium chloride 

Downstream Products

• 33318-86-4 oxalic acid bis-(4-methyl-benzhydryl ester) 
• 38651-11-5 1-(bromo(phenyl)methyl)-4-methylbenzene 
• 130163-27-8 2,3-diphenyl-2,3-di-p-tolyl-oxirane 
• 102078-58-0 (4-chloro-phenyl)-(4-methyl-benzhydryl)-sulfone 
• 113181-46-7 1-methyl-4-((phenyl(p-tolyl)methyl)sulfonyl)benzene 
• 779-14-6 p-methyl-a-phenylbenzylchloride 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 37858-00-7 4,4'-(oxybis(phenylmethylene))bis(methylbenzene) 
• 57272-11-4 1-azido-1-(4-methylphenyl)-1-phenylmethane 
• 134-84-9 4-Methylbenzophenone 
• 42289-57-6 α-p-tolylbenzyl cation 
• 1517-63-1 (-)-p-Methylbenzhydrol 
• 5267-50-5 N-[(4-methylphenyl)(phenyl)methyl]acetamide 
• 1517-63-1 (R)-(4-Methylphenyl)phenylmethanol 

Relevant articles and documents

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Rhodium-catalyzed 1,2-addition of Sb-phenyl-1,5-azastibocines to functionalized aldehydes

Simple and efficient addition of a phenyl group to aldehydes was accomplished by the rhodium-catalyzed reaction of Sb-phenyl-1,5-azastibocines. Because of the soft nucleophilic character of 1,5-azastibocines, arylation of functionalized aldehydes having ketone, ester, and halogen moieties can be achieved to afford aryl alcohols. The reaction can be carried out under aerobic conditions, in striking contrast to the reactions with hard nucleophiles such as organolithium and Grignard reagents.

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes

Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea

Melamine-Based Porous Organic Polymers Supported Pd(II)-Catalyzed Addition of Arylboronic Acids to Aromatic Aldehydes

Abstract: A new type melamine-based porous organic polymers (SZU-1) has been synthesized with melamine and 2,2′-bipyridyl-5,5′-dialdehyde by a one-pot method and fully characterized. Divalent palladium salts were coordinated to this polymer network which successfully catalyzed the nucleophilic addition reaction of arylboronic acids to aromatic aldehydes. With only 1.0?mol% heterogeneous catalyst loading, high reaction yields (>?85%) can be achieved in most cases. The scope of substrates was also investigated and the catalyst showed universal applicability. Graphic Abstract: The loose and porous melamine-based porous organic polymers (SZU-1) are synthesized by melamine and 2,2′-bipyridyl-5,5′-dialdehyde. The performance of SZU-1 was characterized and most of the substrates achieved high yield (> 85%) in the catalytic performance test.[Figure not available: see fulltext.]

Enantioselective Synthesis of Bicyclopentane-Containing Alcohols via Asymmetric Transfer Hydrogenation

Compounds a containing bicyclo[1.1.1]pentane (BCP) adjacent to a chiral center can be prepared with high enantiomeric excess through asymmetric transfer hydrogenation (ATH) of adjacent ketones. In the reduction step, the BCP occupies the position distant from the η6-arene of the catalyst. The reduction was applied to the synthesis of a BCP analogue of the antihistamine drug neobenodine.