153877-56-6

Basic information

• Product Name: 1-(3,5-DIFLUOROPHENYL)ETHANOL
• Synonyms: 1-(3,5-DIFLUOROPHENYL)ETHAN-1-OL;1-(3,5-DIFLUOROPHENYL)ETHANOL;3,5-DIFLUOROPHENYLMETHYLCARBINOL
• CAS NO: 153877-56-6
• Molecular Formula: C8H8F2O
• Molecular Weight: 158.15
• Mol File: 153877-56-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 307.3 °C at 760 mmHg
• Flash Point: 139.6 °C
• Appearance: /
• Density: 1.254 g/cm³
• CAS DataBase Reference: 1-(3,5-DIFLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-DIFLUOROPHENYL)ETHANOL(153877-56-6)
• EPA Substance Registry System: 1-(3,5-DIFLUOROPHENYL)ETHANOL(153877-56-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 153877-56-6(Hazardous Substances Data)

Usage

General Description

1-(3,5-DIFLUOROPHENYL)ETHANOL, also known as difluorophenylethanol, is a chemical compound with the molecular formula C8H7F2O. It is a colorless liquid with a molecular weight of 154.14 g/mol. 1-(3,5-DIFLUOROPHENYL)ETHANOL is often used in pharmaceutical research and can act as a building block in the synthesis of various drugs and other organic compounds. It is also used as a solvent in chemical reactions and as a reagent in organic synthesis. Difluorophenylethanol has potential applications in the development of new medications and chemical processes due to its unique chemical properties. However, it is important to handle this compound with care and adhere to safety guidelines when working with it in a laboratory setting.

Upstream product

• 32085-88-4 3,5-difluorobenzaldehyde 
• 100-59-4 phenylmagnesium chloride 
• 179113-89-4 (3,5-difluorophenyl)(phenyl)methanone 
• 100-58-3 phenylmagnesium bromide 
• 461-96-1 3,5-difluorobromobenzene 
• 100-52-7 benzaldehyde 
• 1224964-68-4 3,5-difluorobenzhydryl bromide 

Downstream Products

• 179113-89-4 (3,5-difluorophenyl)(phenyl)methanone 

Relevant articles and documents

Direct C–H Carboxylation Forming Polyfunctionalized Aromatic Carboxylic Acids by Combined Br?nsted Bases

CO2 fixation into electron-deficient aromatic C–H bonds proceeds with the combined Br?nsted bases LiO-t-Bu and LiO-t-Am/CsF/18-crown-6 (t-Am = CEtMe2) under a CO2 atmosphere to afford a variety of polyfunctionalized aromat

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase-2 (IDO2) which also have been implicated more recently in cancer, inflammation and immune control. Consequently the development of dual or pan inhibitors of these Trp catabolizing enzymes may represent a therapeutically important area of research. This is the first report to describe the development of dual and pan inhibitors of IDO1, TDO and IDO2.